-
Je něco špatně v tomto záznamu ?
Investigation of tadalafil molecular arrangement in solid dispersions using inverse gas chromatography and Raman mapping
T. Školáková, D. Smržová, T. Pekárek, M. Lhotka, A. Školáková, V. Klimša, A. Kadeřábková, P. Zámostný
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- chromatografie plynová MeSH
- polymery * chemie MeSH
- povidon * chemie MeSH
- rozpustnost MeSH
- tadalafil chemie MeSH
- Publikační typ
- časopisecké články MeSH
The aim of this study was to investigate the molecular structures of tadalafil solid dispersions prepared by different techniques and further to relate them to surface free energy information indicating the final amorphousness of the product. Thus, we tried to complement the existing knowledge of solid dispersion formation. Poorly water-soluble tadalafil was combined with different polymers, i.e. Kollidon® 12 PF, Kollidon® VA 64 and Soluplus®, to form model systems. To assess the extent of drug-polymer miscibility, we studied model solid dispersion surface energy using inverse gas chromatography and phase micro-structure using confocal Raman microscopy. The selection of the preparation method was found to play a crucial role in the molecular arrangement of the incorporated drug and the polymer in resulting solid dispersion. Our results showed that a lower surface free energy indicated the formation of a more homogeneous solid dispersion. Conversely, a higher surface free energy corresponded to the heterogeneous systems containing tadalafil amorphous clusters that were captured by Raman mapping. Thus, we successfully introduced a novel evaluation approach of the drug molecular arrangement in solid dispersions that is especially useful for examining the miscibility of the components when the conventional characterizing techniques are inconclusive or yield variable results.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22025165
- 003
- CZ-PrNML
- 005
- 20221031100415.0
- 007
- ta
- 008
- 221017s2022 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ijpharm.2022.121955 $2 doi
- 035 __
- $a (PubMed)35753537
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Školáková, Tereza $u Department of Organic Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic. Electronic address: skolakot@vscht.cz
- 245 10
- $a Investigation of tadalafil molecular arrangement in solid dispersions using inverse gas chromatography and Raman mapping / $c T. Školáková, D. Smržová, T. Pekárek, M. Lhotka, A. Školáková, V. Klimša, A. Kadeřábková, P. Zámostný
- 520 9_
- $a The aim of this study was to investigate the molecular structures of tadalafil solid dispersions prepared by different techniques and further to relate them to surface free energy information indicating the final amorphousness of the product. Thus, we tried to complement the existing knowledge of solid dispersion formation. Poorly water-soluble tadalafil was combined with different polymers, i.e. Kollidon® 12 PF, Kollidon® VA 64 and Soluplus®, to form model systems. To assess the extent of drug-polymer miscibility, we studied model solid dispersion surface energy using inverse gas chromatography and phase micro-structure using confocal Raman microscopy. The selection of the preparation method was found to play a crucial role in the molecular arrangement of the incorporated drug and the polymer in resulting solid dispersion. Our results showed that a lower surface free energy indicated the formation of a more homogeneous solid dispersion. Conversely, a higher surface free energy corresponded to the heterogeneous systems containing tadalafil amorphous clusters that were captured by Raman mapping. Thus, we successfully introduced a novel evaluation approach of the drug molecular arrangement in solid dispersions that is especially useful for examining the miscibility of the components when the conventional characterizing techniques are inconclusive or yield variable results.
- 650 _2
- $a chromatografie plynová $7 D002849
- 650 12
- $a polymery $x chemie $7 D011108
- 650 12
- $a povidon $x chemie $7 D011205
- 650 _2
- $a rozpustnost $7 D012995
- 650 _2
- $a tadalafil $x chemie $7 D000068581
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Smržová, Dominika $u Department of Organic Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
- 700 1_
- $a Pekárek, Tomáš $u Zentiva, k.s., U Kabelovny 130, 102 37 Prague 10, Czech Republic
- 700 1_
- $a Lhotka, Miloslav $u Department of Inorganic Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
- 700 1_
- $a Školáková, Andrea $u Department of Metals and Corrosion Engineering, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
- 700 1_
- $a Klimša, Vojtěch $u Department of Chemical Engineering, University of Chemistry and Technology Prague, Technická 3, 166 28 Prague 6, Czech Republic
- 700 1_
- $a Kadeřábková, Alena $u Department of Polymers, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
- 700 1_
- $a Zámostný, Petr $u Department of Organic Technology, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague 6, Czech Republic
- 773 0_
- $w MED00002359 $t International journal of pharmaceutics $x 1873-3476 $g Roč. 623, č. - (2022), s. 121955
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35753537 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20221017 $b ABA008
- 991 __
- $a 20221031100413 $b ABA008
- 999 __
- $a ok $b bmc $g 1854727 $s 1176455
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 623 $c - $d 121955 $e 20220624 $i 1873-3476 $m International journal of pharmaceutics $n Int. j. pharm. $x MED00002359
- LZP __
- $a Pubmed-20221017
