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Stereotactic Radiosurgery for Vestibular Schwannoma in Neurofibromatosis Type 2: An International Multicenter Case Series of Response and Malignant Transformation Risk
O. Bin-Alamer, A. Faramand, NA. Alarifi, Z. Wei, AN. Mallela, VM. Lu, AM. Nabeel, WA. Reda, SR. Tawadros, K. Abdelkarim, AMN. El-Shehaby, RM. Emad, S. Peker, Y. Samanci, CC. Lee, HC. Yang, V. Delabar, D. Mathieu, M. Tripathi, KN. Kearns, A....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu multicentrická studie, časopisecké články
- MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádorová transformace buněk MeSH
- následné studie MeSH
- nedoslýchavost * chirurgie MeSH
- neurofibromatóza 2 * komplikace chirurgie MeSH
- radiochirurgie * škodlivé účinky MeSH
- retrospektivní studie MeSH
- vestibulární schwannom * komplikace radioterapie chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Vestibular schwannomas (VSs) related to neurofibromatosis type 2 (NF2) are challenging tumors. The increasing use of stereotactic radiosurgery (SRS) necessitates further investigations of its role and safety. OBJECTIVE: To evaluate tumor control, freedom from additional treatment (FFAT), serviceable hearing preservation, and radiation-related risks of patients with NF2 after SRS for VS. METHODS: We performed a retrospective study of 267 patients with NF2 (328 VSs) who underwent single-session SRS at 12 centers participating in the International Radiosurgery Research Foundation. The median patient age was 31 years (IQR, 21-45 years), and 52% were male. RESULTS: A total of 328 tumors underwent SRS during a median follow-up time of 59 months (IQR, 23-112 months). At 10 and 15 years, the tumor control rates were 77% (95% CI: 69%-84%) and 52% (95% CI: 40%-64%), respectively, and the FFAT rate were 85% (95% CI: 79%-90%) and 75% (95% CI: 65%-86%), respectively. At 5 and 10 years, the serviceable hearing preservation rates were 64% (95% CI: 55%-75%) and 35% (95% CI: 25%-54%), respectively. In the multivariate analysis, age (hazards ratio: 1.03 [95% CI: 1.01-1.05]; P = .02) and bilateral VSs (hazards ratio: 4.56 [95% CI: 1.05-19.78]; P = .04) were predictors for serviceable hearing loss. Neither radiation-induced tumors nor malignant transformation were encountered in this cohort. CONCLUSION: Although the absolute volumetric tumor progression rate was 48% at 15 years, the rate of FFAT related to VS was 75% at 15 years after SRS. None of the patients with NF2-related VS developed a new radiation-related neoplasm or malignant transformation after SRS.
Clinical Oncology Department Ain Shams University Cairo Egypt
Department of Neurological Surgery University of Miami School of Medicine Miami Florida USA
Department of Neurological Surgery University of Virginia Charlottesville Virginia USA
Department of Neurosurgery Koc University School of Medicine Istanbul Turkey
Department of Neurosurgery Neurological Institute Taipei Veteran General Hospital Taipei Taiwan
Department of Neurosurgery West Virginia University Morgantown West Virginia USA
Department of Radiation Oncology Beaumont Health System Royal Oak Michigan USA
Gamma Knife Center Cairo Nasser Institute Hospital Cairo Egypt
Neurosurgery Department Ain Shams University Cairo Egypt
Neurosurgery Department Benha University Qalubya Egypt
Radiation Oncology Department National Cancer Institute Cairo University Cairo Egypt
Radiosurgery Unit Hospital Ruber Internacional Madrid Spain
School of Medicine National Yang Ming University Taipei Taiwan
Stereotactic and Radiation Neurosurgery Na Homolce Hospital Prague Czech Republic
Citace poskytuje Crossref.org
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