Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Undifferentiated Carcinoma with Osteoclast-like Giant Cells of the Pancreas: Molecular Genetic Analysis of 13 Cases

J. Hrudka, M. Kalinová, V. Ciprová, J. Moravcová, R. Dvořák, R. Matěj

. 2024 ; 25 (6) : . [pub] 20240314

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24006726

Grantová podpora
Cooperatio Medical Diagnostics Charles University

Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a rare malignancy regarded as a subvariant of pancreatic ductal carcinoma (PDAC) characterized by variable prognosis. UCOGC shows a strikingly similar spectrum of oncogenic DNA mutations to PDAC. In the current work, we analyzed the landscape of somatic mutations in a set of 13 UCOGC cases via next-generation sequencing (NGS). We detected a spectrum of pathogenic or likely pathogenic mutations similar to those observed in PDAC following previously published results (10 KRAS, 9 TP53, 4 CDKN2A, and 1 SMAD4, CIC, GNAS, APC, ATM, NF1, FBXW7, ATR, and FGFR3). Our results support the theory that UCOGC is a variant of PDAC, despite its unique morphology; however, a UCOGC-specific genomic signature as well as predictive markers remain mainly unknown. Programmed death ligand 1 (PD-L1) status remains an important predictive marker based on previous studies.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24006726
003      
CZ-PrNML
005      
20240423155451.0
007      
ta
008      
240412s2024 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/ijms25063285 $2 doi
035    __
$a (PubMed)38542259
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Hrudka, Jan $u Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $1 https://orcid.org/0000000256494586
245    10
$a Undifferentiated Carcinoma with Osteoclast-like Giant Cells of the Pancreas: Molecular Genetic Analysis of 13 Cases / $c J. Hrudka, M. Kalinová, V. Ciprová, J. Moravcová, R. Dvořák, R. Matěj
520    9_
$a Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) of the pancreas is a rare malignancy regarded as a subvariant of pancreatic ductal carcinoma (PDAC) characterized by variable prognosis. UCOGC shows a strikingly similar spectrum of oncogenic DNA mutations to PDAC. In the current work, we analyzed the landscape of somatic mutations in a set of 13 UCOGC cases via next-generation sequencing (NGS). We detected a spectrum of pathogenic or likely pathogenic mutations similar to those observed in PDAC following previously published results (10 KRAS, 9 TP53, 4 CDKN2A, and 1 SMAD4, CIC, GNAS, APC, ATM, NF1, FBXW7, ATR, and FGFR3). Our results support the theory that UCOGC is a variant of PDAC, despite its unique morphology; however, a UCOGC-specific genomic signature as well as predictive markers remain mainly unknown. Programmed death ligand 1 (PD-L1) status remains an important predictive marker based on previous studies.
650    _2
$a lidé $7 D006801
650    12
$a nádory slinivky břišní $x genetika $x patologie $7 D010190
650    _2
$a osteoklasty $x patologie $7 D010010
650    _2
$a pankreas $x patologie $7 D010179
650    12
$a duktální karcinom slinivky břišní $x patologie $7 D021441
650    _2
$a obrovské buňky $x patologie $7 D015726
650    _2
$a mutace $7 D009154
650    _2
$a molekulární biologie $7 D008967
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kalinová, Markéta $u Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $u Central Laboratories, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic
700    1_
$a Ciprová, Vanda $u Department of Pathology, 1st Faculty of Medicine, Charles University, General University Hospital, 128 00 Prague, Czech Republic
700    1_
$a Moravcová, Jana $u Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $u Clinical and Transplant Pathology Center, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic
700    1_
$a Dvořák, Radim $u Department of General Surgery, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic
700    1_
$a Matěj, Radoslav $u Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $u Department of Pathology, 1st Faculty of Medicine, Charles University, General University Hospital, 128 00 Prague, Czech Republic $u Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine, Charles University, Thomayer University Hospital, 140 59 Prague, Czech Republic $1 https://orcid.org/0000000261526343
773    0_
$w MED00176142 $t International journal of molecular sciences $x 1422-0067 $g Roč. 25, č. 6 (2024)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/38542259 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240412 $b ABA008
991    __
$a 20240423155447 $b ABA008
999    __
$a ok $b bmc $g 2080991 $s 1216493
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 25 $c 6 $e 20240314 $i 1422-0067 $m International journal of molecular sciences $n Int J Mol Sci $x MED00176142
GRA    __
$a Cooperatio Medical Diagnostics $p Charles University
LZP    __
$a Pubmed-20240412

Najít záznam

Citační ukazatele

Možnosti archivace