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Plasma lipidome differences in patients with and without significant carotid plaque

M. Malý, O. Kučerka, K. Bechyňská, K. Kočí, V. Mandys, J. Hajšlová, V. Kosek

. 2024 ; 155 (-) : 107377. [pub] 20240503

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, srovnávací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc24013647

BACKGROUND: Atherosclerosis is a major cause of ischemic stroke, and early detection of advanced atherosclerosis in the carotid artery is important for reducing morbidity and mortality. What is even more important is not only detection of atherosclerosis but early determination whether the patients are at high risk of an event with adverse effects as the size of the plaque does not necessarily reflect its potential to trigger such events. AIM: We studied whether plasma lipidomics profile can be used as a diagnostic tool for stratification of stable or unstable plaques without the need of removing the carotid plaque. METHODS: This study used liquid chromatography high-resolution tandem mass spectrometry lipidomics to characterize lipid profiles in patients' plasma and found that patients with significant and complicated (vulnerable) atherosclerotic plaque had distinct lipid profiles compared to those with insignificant plaques. RESULTS: The lipid classes that were most predictive of vulnerable plaque were lysophosphoethanolamines, fatty acyl esters of hydroxy fatty acids, free fatty acids, plasmalogens, and triacylglycerols. Most of these compounds were found decreased in plasma of patients with unstable plaques which enabled sufficient performance of a statistical model used for patient stratification. CONCLUSIONS: Plasma lipidomes measured by liquid chromatography-mass spectrometry show differences in patients with stable and unstable carotid plaques, therefore these compounds could potentially be used as biomarkers for unstable plaque in future clinical diagnosis.

Citace poskytuje Crossref.org

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$a Kučerka, Ondřej $u Department of Medicine, First Faculty of Medicine, Charles University in Prague and the Military University Hospital, Prague 16902, Czech Republic; Department of Military Internal Medicine and Military Hygiene, Faculty of Military Health Sciences, University of Defence, Hradec Kralove 50002, Czech Republic
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$a Bechyňská, Kamila $u University of Chemistry and Technology, Department of Food Chemistry and Analysis, Technická 3, Prague 6 166 28, Czech Republic
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$a Kočí, Karolína $u Department of Medicine, First Faculty of Medicine, Charles University in Prague and the Military University Hospital, Prague 16902, Czech Republic
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$a Mandys, Václav $u Department of Pathology, Third Faculty of Medicine, Charles University and the University Hospital Kralovske Vinohrady, Prague 100 00, Czech Republic
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$a Kosek, Vít $u University of Chemistry and Technology, Department of Food Chemistry and Analysis, Technická 3, Prague 6 166 28, Czech Republic. Electronic address: kosekv@vscht.cz
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