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A Short Retrospective Cytometric Note on Myeloblasts in Patients Suffering from Acute Myeloblastic Leukaemia, Myelodysplastic Syndrome and Chronic Myelocytic Leukaemia: Myeloblasts with a Narrow Cytoplasm without Azurophilic Granules Are Less Differentiated Committed Progenitor Stem Cells
K. Smetana, H. Klamová, R. Šimečková, D. Mikulenková
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Grantová podpora
DRO IHBT 00023736
Ministerstvo Zdravotnictví Ceské Republiky
NLK
Free Medical Journals
od 2000
Freely Accessible Science Journals
od 2000
ProQuest Central
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2000
PubMed
39889219
DOI
10.14712/fb2024070050270
Knihovny.cz E-zdroje
- MeSH
- akutní myeloidní leukemie * patologie MeSH
- buněčná diferenciace * MeSH
- chronická myeloidní leukemie * patologie MeSH
- cytoplazma * metabolismus MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- myelodysplastické syndromy * patologie MeSH
- prekurzorové buňky granulocytů patologie MeSH
- retrospektivní studie MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The maximal nuclear and cell body diameters of leukaemic agranular myeloblasts ("type 1" without azurophilic granules) were measured in bone marrow smears of patients suffering from acute myeloblastic leukaemia with minimal differentiation (M0 AML), without and with maturation (M1 and M2 AML), refractory anaemia with excess of myeloblasts (RAEB) and chronic phase of the myeloid leukaemia (CML) to provide more information on the cytoplasmic space estimate occupied by the nucleus. The largest size of the cytoplasmic space occupied by the nucleus in agranular myeloblasts was noted in M0 and M1 AML in comparison with M2 AML or RAEB, and especially with CML. Similarly, agranular myeloblasts with nuclear bodies occupying more than 90 per cent of the cell space were most frequent in M0 and M1 AML (> 50 %), less frequent in M2 and RAEB (~ 20 %) but very rare in CML (~ 5 %). According to electron microscopy, the very narrow cytoplasmic shell surrounding the nucleus in such myeloblasts did not possess any space for structural components characteristic of the granulocytic cell lineage. Thus, the basic morphology of these myeloblasts would correspond to morphological features of a less differentiated committed stem cell. It should be noted that such cells may be easily recognized in currently stained bone marrow or peripheral blood smears.
Citace poskytuje Crossref.org
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