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Alveolar Bile and Light Chain Immunoglobulin Depositions as an Unusual Complication of Transjugular Liver Biopsy Resulting in Bilhemia in a Patient with Multiple Myeloma

S. Farkašová Iannaccone, S. Dražilová, R. Matěj, M. Takáčová, P. Bohuš, P. Jarčuška, A. Šmirjáková, A. Ginelliová, L. Fröhlichová, Š. Pataky, M. Kička, Z. Szamosi, D. Farkaš

. 2025 ; 14 (6) : . [pub] 20250311

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu kazuistiky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25008243

Background: A 69-year-old man with multiple myeloma and left-sided heart failure presented to the hospital with a two-month fever. Method: A transjugular liver biopsy was performed due to the rapid progression of liver failure. The procedure was complicated by an intraperitoneal hemorrhage. The bleeding was managed expectantly. Result: Significantly elevated serum bilirubin levels occurred on the 13th day after liver biopsy. Increasing serum bilirubin levels were observed until the patient's death due to a biliovenous fistula at the liver biopsy site. Simultaneously, his slightly elevated liver enzymes returned to normal. The patient died 23 days after liver biopsy due to acute respiratory distress syndrome. Fistulous communication between the biliary tree and the hepatic venous system with subsequent bile leakage into the venous system (bilhemia) can lead to bile deposition in the lungs. Bile deposition in the lungs may potentiate and accelerate the development of diffuse alveolar damage with hyaline membranes. Conclusions: Lambda and kappa light chain deposition in the pulmonary alveoli in patients with multiple myeloma can mimic typical hyaline membranes.

Citace poskytuje Crossref.org

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$a Farkašová Iannaccone, Silvia $u Department of Forensic Medicine, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 041 11 Košice, Slovakia
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$a Background: A 69-year-old man with multiple myeloma and left-sided heart failure presented to the hospital with a two-month fever. Method: A transjugular liver biopsy was performed due to the rapid progression of liver failure. The procedure was complicated by an intraperitoneal hemorrhage. The bleeding was managed expectantly. Result: Significantly elevated serum bilirubin levels occurred on the 13th day after liver biopsy. Increasing serum bilirubin levels were observed until the patient's death due to a biliovenous fistula at the liver biopsy site. Simultaneously, his slightly elevated liver enzymes returned to normal. The patient died 23 days after liver biopsy due to acute respiratory distress syndrome. Fistulous communication between the biliary tree and the hepatic venous system with subsequent bile leakage into the venous system (bilhemia) can lead to bile deposition in the lungs. Bile deposition in the lungs may potentiate and accelerate the development of diffuse alveolar damage with hyaline membranes. Conclusions: Lambda and kappa light chain deposition in the pulmonary alveoli in patients with multiple myeloma can mimic typical hyaline membranes.
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$a Dražilová, Sylvia $u 2nd Department of Internal Medicine, Pavol Jozef Šafárik University, Louis Pasteur University Hospital, Trieda SNP 1, 040 11 Košice, Slovakia
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$a Matěj, Radoslav $u Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine, Charles University, Thomayer University Hospital, Vídeňská 800, 140 59 Prague, Czech Republic $1 https://orcid.org/0000000261526343
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$a Takáčová, Miroslava $u Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Košice, Slovakia
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$a Bohuš, Peter $u Department of Pathology, Louis Pasteur University Hospital, Rastislavova 43, 040 01 Košice, Slovakia
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