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Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in systemic mastocytosis: a registry study of the European Competence Network on Mastocytosis
A. Rüfer, H. Nilius, O. Hermine, M. Niedoszytko, JNG. Oude Elberink, P. Bonadonna, K. Shoumariyeh, T. Gulen, K. Hartmann, V. Sabato, I. Angelova-Fischer, D. Baffoe, D. Christen, A. Belloni Fortina, C. Breynaert, K. Brockow, N. von Bubnoff, H....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
- MeSH
- antigen Ki-1 * metabolismus MeSH
- antigeny CD2 * metabolismus MeSH
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mastocyty * metabolismus patologie imunologie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- prognóza MeSH
- receptor interleukinu-2 - alfa-podjednotka * metabolismus MeSH
- registrace * MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- systémová mastocytóza * metabolismus patologie mortalita diagnóza MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Evropa MeSH
Expression of CD2, CD25 and/or CD30 in extracutaneous mast cells (MC) is a minor diagnostic criterion for systemic mastocytosis (SM) in the classification of the World Health Organization and International Consensus Classification. So far, it remains unknown whether expression of these antigens on MC is of prognostic significance in SM. We performed a retrospective multi-center study of patients with SM using the data set of the registry of the European Competence Network on Mastocytosis, including 5034 patients with various MC disorders. The percentage of CD2-, CD25+ and/or CD30+ MC was considerably lower in patients with indolent SM compared to patients with advanced SM, including aggressive SM and MC leukemia. Whereas CD25 and CD30 expression in MC could not be associated with prognosis, we found that lack of CD2 expression in MC is associated with a significantly reduced overall survival (OS) in patients with SM (p < 0.0001). Lack of CD2 was also associated with the presence of extramedullary involvement affecting the spleen, liver, and/or lymph nodes (odds ratio 2.63 compared to SM with CD2+ MC). Together, lack of CD2 expression in MC is a prognostic marker and indicator of reduced OS and extramedullary disease expansion in patients with SM.
Allergy Unit Azienda Ospedaliera Universitaria Integrata di Verona Verona Italy
Brno University Hospital Brno Czech Republic
Department of Allergology Medical University of Gdansk Gdansk Poland
Department of Clinical Chemistry University Hospital Bern Inselspital Bern Switzerland
Department of Hematology Luzerner Kantonsspital University of Luzern Luzern Switzerland
Department of Hematology Semmelweis University Budapest Hungary
Department of Internal Medicine Erasmus University Rotterdam Rotterdam The Netherlands
Department of Medicine 1 Medical Center University of Freiburg Faculty of Medicine Freiburg Germany
Department of Respiratory Medicine and Allergy Karolinska University Hospital Huddinge Stockholm
Departments of Hematology and Pharmacology Oslo University Hospital Rikshospitalet Oslo Norway
Division of Allergy and Clinical Immunology University of Salerno Salerno Italy
Division of Hematology Istanbul Medical School University of Istanbul Istanbul Turkey
German Cancer Consortium Heidelberg Germany
Kantonsspital Aarau AG Medizinische Universitätsklinik Hämatologie Aarau Switzerland
Klinik für Dermatologie und Venerologie Kepler Universitätsklinikum Linz Austria
Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein
Ludwig Boltzmann Institute for Hematology and Oncology Medical University of Vienna Vienna Austria
Mastocytosis Center Attikon University Hospital of Athens Athens Greece
Medical Clinic 1 Universitätsklinikum Leipzig AöR Leipzig Germany
Pediatric Dermatology Internal Medicine Azienda Ospedaliera Università di Padova Padova Italy
Policlinico San Matteo Pavia Fondazione IRCCS Pavia Italy
S C Ematologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy
Stanford Cancer Institute Stanford University School of Medicine Stanford CA USA
Technische Universität München München Germany
Universitätsklinik für Dermatologie und Venerologie Medical University of Graz Graz Austria
Universitätsspital Basel Basel Switzerland
Universiteit Antwerpen Campus Drie Eiken Antwerp Belgium
University Medical Center Groningen University of Groningen Groningen The Netherlands
Citace poskytuje Crossref.org
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