Sex-linked, androgen-dependent differences in renal retention of trimethylselenonium ions
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1384616
DOI
10.1007/bf02783681
Knihovny.cz E-zdroje
- MeSH
- krysa rodu Rattus MeSH
- ledviny účinky léků metabolismus MeSH
- pohlavní dimorfismus * MeSH
- pohlavní dospělost MeSH
- potkani Wistar MeSH
- selen metabolismus MeSH
- sloučeniny selenu * MeSH
- testosteron farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- selen MeSH
- sloučeniny selenu * MeSH
- testosteron MeSH
- trimethylselenonium MeSH Prohlížeč
The metabolism of trimethylselenonium ions (TMSe) was studied in male and female rats during maturation. Selenium (Se) retention in the whole body as well as in organs was found to be significantly higher in male rats than in female a few hours after parenteral administration of TMSe. The pronounced Se accumulation was observed in male kidneys. This sex-linked difference was dependent on the presence of gonads and started to be manifested with sexual maturation during the third decade of postnatal life. The effects of steroid hormones on the retention of Se from TMSe were examined in female and castrated male rats. The results indicate that TMSe metabolism in rat kidneys may be influenced by androgen steroids.
