Regionální chemoterapie u experimentálního cholangiokarcinomu veprů
[Regional chemotherapy in experimental cholangiocarcinoma in pigs]
Jazyk čeština Země Česko Médium print
Typ dokumentu anglický abstrakt, časopisecké články
PubMed
9748745
- MeSH
- chemoterapie nádorů pomocí regionální perfúze * MeSH
- cholangiokarcinom farmakoterapie MeSH
- nádory žlučových cest farmakoterapie MeSH
- prasata MeSH
- protokoly protinádorové kombinované chemoterapie terapeutické užití MeSH
- žlučové cesty intrahepatální * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
BACKGROUND: Primary cholangiocarcinoma (PCC) accounts for cca 9% of all carcinomas of the liver and biliary system. Its prognosis of always unfavourable and treatment is difficult. METHODS AND RESULTS: In 25 pigs strain BU PCC was induced chemically with the aim to test the action of regional chemotherapy on the tumor tissue. For treatment 5-fluorouracil, 5-fluoro-2-deoxyuridine, mitomycin C and doxorubicin was used either as monotherapy or in combinations. During chemotherapy a significant reduction of the tumour or fibrotization occurred, as compared with animals not receiving treatment. The median of survival was prolonged from 51.3 to 210.3 days. CONCLUSIONS: Regional chemotherapy is a significant constituent of oncological treatment of PCC. Complications of treatment are negligible and the rest for further treatment are encouraging.
