The role of Klebsiella pneumoniae K- and O-polysaccharide antigens was determined in a rat model of lobar pneumonia. The induction of experimental infection in rats by wild-type strain, and its lipopolysaccharide- and capsular polysaccharide-deficient mutants was compared. Though the mutant lacking both antigens (K- O-) induced infection it could not successfully establish itself in the rat lung. It caused only mild infection, as compared to the wild type strain (K+ O+) and the strain lacking CPS alone (K- O+). Besides capsular polysaccharide, the lipopolysaccharide antigen was shown to be an important factor in pathogenesis of K. pneumoniae acute respiratory tract infection.

Department of Microbiology Panjab University Chandigarh 160 014 India

Zobrazit více v PubMed

J Med Microbiol. 1986 Mar;21(2):133-7 PubMed

FEMS Microbiol Lett. 1993 Jul 15;111(1):9-13 PubMed

Am Rev Respir Dis. 1983 Jan;127(1):110-2 PubMed

J Infect Dis. 1986 Oct;154(4):682-8 PubMed

Infect Control. 1985 Feb;6(2):75-7 PubMed

Infect Immun. 1992 May;60(5):1771-8 PubMed

Infect Immun. 2000 Feb;68(2):953-5 PubMed

Infect Immun. 1984 Jan;43(1):440-1 PubMed

Infect Immun. 1986 Oct;54(1):85-9 PubMed

ILAR J. 1999;40(4):167-174 PubMed

Infect Immun. 1982 Jul;37(1):327-35 PubMed

Microbiol Rev. 1983 Mar;47(1):46-83 PubMed

Infect Control. 1985 Feb;6(2):68-74 PubMed

J Med Microbiol. 2000 Nov;49(11):1003-10 PubMed

Clin Microbiol Rev. 1998 Oct;11(4):589-603 PubMed

Can J Microbiol. 1990 Dec;36(12):885-90 PubMed

Folia Microbiol (Praha). 2002;47(4):445-9 PubMed

Antibiotic-induced release of inflammatory mediators from bacteria in experimental Klebsiella pneumoniae-induced sepsis

Lipopolysaccharide-mediated protection against Klebsiella pneumoniae-induced lobar pneumonia: intranasal vs. intramuscular route of immunization