1H MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy

. 2009 Feb ; 19 (2) : 400-8. [epub] 20080830

Jazyk angličtina Země Německo Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid18758785

The aim of the study was to analyze the lateralizing value of proton magnetic resonance spectroscopy ((1)H MRS) in histopathologically different subgroups of mesial temporal lobe epilepsies (MTLE) and to correlate results with clinical, MRI and seizure outcome data. A group of 35 patients who underwent resective epilepsy surgery was retrospectively studied. Hippocampal (1)H MR spectra were evaluated. Metabolite concentrations were obtained using LCModel and NAA/Cr, NAA/Cho, NAA/(Cr+Cho), Cho/Cr ratios and coefficients of asymmetry were calculated. MRI correctly lateralized 89% of subjects and (1)H MRS 83%. MRI together with (1)H MRS correctly lateralized 100% of patients. Nineteen subjects had "classical" hippocampal sclerosis (HS), whereas the remaining 16 patients had "mild" HS. Nineteen patients had histopathologically proven malformation of cortical development (MCD) in the temporal pole; 16 subjects had only HS. No difference in (1)H MRS findings was found between patients in different histopathological subgroups of MTLE. Our results support the hypothesis that (1)H MRS abnormalities do not directly reflect histopathological changes in MTLE patients. Subjects with non-lateralized (1)H MRS abnormalities did not have a worse postoperative seizure outcome. We found no significant impact of contralateral (1)H MRS abnormality on post-surgical seizure outcome.

Zobrazit více v PubMed

Epilepsia. 2007 Feb;48(2):263-9 PubMed

Arch Pathol Lab Med. 1996 Jun;120(6):532-6 PubMed

AJNR Am J Neuroradiol. 2002 Sep;23(8):1359-68 PubMed

Childs Nerv Syst. 2000 Apr;16(4):235-41 PubMed

Neurology. 2004 Mar 23;62(6 Suppl 3):S2-8 PubMed

Eur Radiol. 2007 Aug;17(8):2126-35 PubMed

J Comput Assist Tomogr. 2000 Nov-Dec;24(6):919-26 PubMed

J Neurosurg. 2004 Oct;101(4):613-20 PubMed

Neurology. 1997 Dec;49(6):1525-33 PubMed

Magn Reson Med. 1993 Dec;30(6):672-9 PubMed

Neurology. 2002 Aug 27;59(4):633-6 PubMed

AJNR Am J Neuroradiol. 1997 Nov-Dec;18(10):1872-9 PubMed

Magn Reson Imaging. 1995;13(8):1187-91 PubMed

Acta Neurol Scand. 2003 Oct;108(4):223-38 PubMed

J Magn Reson Imaging. 2002 Oct;16(4):477-83 PubMed

Neurology. 1998 Mar;50(3):748-54 PubMed

Epilepsia. 2001 Mar;42(3):417-22 PubMed

Epilepsia. 2001 Jan;42(1):41-6 PubMed

Neurology. 2001 Jun 26;56(12):1643-9 PubMed

Neurology. 1999 Sep 11;53(4):694-8 PubMed

Arch Neurol. 2001 Dec;58(12):2048-53 PubMed

AJNR Am J Neuroradiol. 2001 Apr;22(4):625-31 PubMed

Neurosurgery. 1995 Nov;37(5):982-90; discussion 990-1 PubMed

Ann Neurol. 1996 Jan;39(1):107-13 PubMed

Eur Radiol. 2003 May;13(5):994-1000 PubMed

MAGMA. 1998 Dec;7(2):95-114 PubMed

Epilepsy Res. 2006 Oct;71(2-3):149-58 PubMed

Ann Neurol. 2000 Feb;47(2):195-200 PubMed

Epilepsia. 2001 Feb;42(2):190-7 PubMed

Rev Neurol (Paris). 1999 Jul;155(6-7):495-8 PubMed

MAGMA. 2003 Nov;16(3):135-43 PubMed

Acta Neurol Scand. 2004 Feb;109(2):126-31 PubMed

Epilepsia. 2004;45 Suppl 4:17-23 PubMed

Ann Neurol. 1993 Dec;34(6):788-94 PubMed

Epilepsia. 2002 Sep;43(9):1021-31 PubMed

Neurology. 1994 Oct;44(10):1841-5 PubMed

Neurology. 2002 May 28;58(10):1505-12 PubMed

Neuroradiology. 2001 Sep;43(9):721-7 PubMed

Ann Neurol. 1997 Nov;42(5):737-46 PubMed

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...