1H MR spectroscopy in histopathological subgroups of mesial temporal lobe epilepsy
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dospělí MeSH
- elektroencefalografie metody MeSH
- epilepsie temporálního laloku diagnóza patologie chirurgie MeSH
- hipokampus patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie metody MeSH
- magnetická rezonanční tomografie metody MeSH
- mladiství MeSH
- reprodukovatelnost výsledků MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The aim of the study was to analyze the lateralizing value of proton magnetic resonance spectroscopy ((1)H MRS) in histopathologically different subgroups of mesial temporal lobe epilepsies (MTLE) and to correlate results with clinical, MRI and seizure outcome data. A group of 35 patients who underwent resective epilepsy surgery was retrospectively studied. Hippocampal (1)H MR spectra were evaluated. Metabolite concentrations were obtained using LCModel and NAA/Cr, NAA/Cho, NAA/(Cr+Cho), Cho/Cr ratios and coefficients of asymmetry were calculated. MRI correctly lateralized 89% of subjects and (1)H MRS 83%. MRI together with (1)H MRS correctly lateralized 100% of patients. Nineteen subjects had "classical" hippocampal sclerosis (HS), whereas the remaining 16 patients had "mild" HS. Nineteen patients had histopathologically proven malformation of cortical development (MCD) in the temporal pole; 16 subjects had only HS. No difference in (1)H MRS findings was found between patients in different histopathological subgroups of MTLE. Our results support the hypothesis that (1)H MRS abnormalities do not directly reflect histopathological changes in MTLE patients. Subjects with non-lateralized (1)H MRS abnormalities did not have a worse postoperative seizure outcome. We found no significant impact of contralateral (1)H MRS abnormality on post-surgical seizure outcome.
Zobrazit více v PubMed
Epilepsia. 2007 Feb;48(2):263-9 PubMed
Arch Pathol Lab Med. 1996 Jun;120(6):532-6 PubMed
AJNR Am J Neuroradiol. 2002 Sep;23(8):1359-68 PubMed
Childs Nerv Syst. 2000 Apr;16(4):235-41 PubMed
Neurology. 2004 Mar 23;62(6 Suppl 3):S2-8 PubMed
Eur Radiol. 2007 Aug;17(8):2126-35 PubMed
J Comput Assist Tomogr. 2000 Nov-Dec;24(6):919-26 PubMed
J Neurosurg. 2004 Oct;101(4):613-20 PubMed
Neurology. 1997 Dec;49(6):1525-33 PubMed
Magn Reson Med. 1993 Dec;30(6):672-9 PubMed
Neurology. 2002 Aug 27;59(4):633-6 PubMed
AJNR Am J Neuroradiol. 1997 Nov-Dec;18(10):1872-9 PubMed
Magn Reson Imaging. 1995;13(8):1187-91 PubMed
Acta Neurol Scand. 2003 Oct;108(4):223-38 PubMed
J Magn Reson Imaging. 2002 Oct;16(4):477-83 PubMed
Neurology. 1998 Mar;50(3):748-54 PubMed
Epilepsia. 2001 Mar;42(3):417-22 PubMed
Epilepsia. 2001 Jan;42(1):41-6 PubMed
Neurology. 2001 Jun 26;56(12):1643-9 PubMed
Neurology. 1999 Sep 11;53(4):694-8 PubMed
Arch Neurol. 2001 Dec;58(12):2048-53 PubMed
AJNR Am J Neuroradiol. 2001 Apr;22(4):625-31 PubMed
Neurosurgery. 1995 Nov;37(5):982-90; discussion 990-1 PubMed
Ann Neurol. 1996 Jan;39(1):107-13 PubMed
Eur Radiol. 2003 May;13(5):994-1000 PubMed
MAGMA. 1998 Dec;7(2):95-114 PubMed
Epilepsy Res. 2006 Oct;71(2-3):149-58 PubMed
Ann Neurol. 2000 Feb;47(2):195-200 PubMed
Epilepsia. 2001 Feb;42(2):190-7 PubMed
Rev Neurol (Paris). 1999 Jul;155(6-7):495-8 PubMed
MAGMA. 2003 Nov;16(3):135-43 PubMed
Acta Neurol Scand. 2004 Feb;109(2):126-31 PubMed
Epilepsia. 2004;45 Suppl 4:17-23 PubMed
Ann Neurol. 1993 Dec;34(6):788-94 PubMed
Epilepsia. 2002 Sep;43(9):1021-31 PubMed
Neurology. 1994 Oct;44(10):1841-5 PubMed
Neurology. 2002 May 28;58(10):1505-12 PubMed
Neuroradiology. 2001 Sep;43(9):721-7 PubMed
Ann Neurol. 1997 Nov;42(5):737-46 PubMed