Curative therapies for Ewing sarcoma have been developed within cooperative groups. Consecutive clinical trials have systematically assessed the impact and timing of local therapy and the activity of cytotoxic drugs and their combinations. They have led to an increase of long-term disease-free survival to around 70% in patients with localized disease. Translational research in ES remains an area in which interdisciplinary and international cooperation is essential for future progress. This article reviews current state-of-the art therapy, with a focus on trials performed in Europe, and summarizes novel strategies to further advance both the cure rates and quality of survival.

Alder Hey Children's National Health Service Foundation Trust Liverpool UK

Clinic for Particle Therapy West German Proton Therapy Center Essen West German Cancer Center University Hospital Essen

Clinic of Pediatric Oncology Hematology and Clinical Immunology Heinrich Heine University Duesseldorf Germany

Department of Clinical Radiology University Hospital Muenster Muenster Germany

Department of Nuclear Medicine University of Münster Münster Germany

Department of Orthopedic Surgery University Hospital Muenster Muenster Germany

Department of Paediatric Haematology and Oncology Charles University 2nd School of Medicine Prague Czech Republic

Department of Pediatrics Klinikum rechts der Isar Technische Universität München Munich Germany

Department of Pediatrics University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia Philadelphia Pennsylvania USA

Department of Radiation Oncology University of Luebeck and University Medical Center Schleswig Holstein Campus Luebeck Germany

Department of Radiation Therapy University of Erlangen Erlangen Germany

Department of Radiotherapy and Radiation Oncology Saarland University Medical Center Homburg Germany

Department of Radiotherapy University Hospital Muenster Muenster Germany

Department Osnabrueck Center for Radiotherapy Rheine Osnabrueck Osnabrueck Germany

Emma Children Hospital AMC University of Amsterdam Amsterdam the Netherlands

Gustave Roussy Institute Villejuif France

Inserm U830 Laboratory of Genetics and Biology of Cancers Institut Curie Paris France

Institute of Biostatistics and Clinical Research University of Muenster Muenster Germany

Institute of Experimental Musculoskeletal Medicine University Hospital Muenster Muenster Germany

Kiel Paediatric Tumor Registry Department of Paediatric Pathology Christian Albrechts University Kiel Kiel Germany

NIHR University College London Hospitals Biomedical Research Centre London UK

Pediatric Hematology and Oncology Muenster University Children's Hospital Muenster Germany

Royal Victoria Infirmary Newcastle United Kingdom

Seattle Children's Hospital and Fred Hutchinson Cancer Research Center University of Washington Seattle Washington USA

Skåne University Hospital Lund University Lund Sweden

St Anna Kinderkrebsforschung e 5 Children's Cancer Research Institute and Department of Pediatrics Medical University Vienna

Université Paris Sud Le Kremlin Bicêtre and Gustave Roussy Institute Villejuif France

Vestische Kinder und Jugendklinik Datteln Witten Herdecke University Datteln Germany

Zentrum für Pathologie Kempten Allgäu Kempten Germany

Klin Padiatr. 2015 May;227(3):105-7. doi: 10.1055/s-0035-1548751. PubMed

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