The incidence of MYB gene breaks in adenoid cystic carcinoma of the salivary glands and its prognostic significance
Jazyk angličtina Země Česko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
27174194
DOI
10.5507/bp.2016.027
Knihovny.cz E-zdroje
- Klíčová slova
- MYB gene, adenoid cystic carcinoma, prognosis, salivary gland,
- MeSH
- adenoidně cystický karcinom genetika mortalita MeSH
- dospělí MeSH
- genetická predispozice k nemoci genetika MeSH
- geny myb genetika MeSH
- hybridizace in situ fluorescenční MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory slinných žláz genetika mortalita MeSH
- prognóza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks. The Kaplan-Meier survival analysis was used to estimate prognosis. RESULTS: Fifteen of 23 evaluated tumours were MYB positive and 8 MYB negative. The 10-year cumulative survival, respectively disease free interval, was 60.0%, respectively 59.3%, in MYB positive patients and 88.5%, respectively 80.0%, in MYB negative patients (long rank test, P=0.23). There were no significant differences in age, gender, perineural invasion, the presence of hematogenic or nodal metastases or degree of histopathological grading between MYB positive and MYB negative patients. CONCLUSION: A tendency to differences in the survival of patients with ACC, depending on their MYB status. MYB negative patients were predisposed to better prognosis.
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