Association of HLA-DRB1 and HLA-DQB1 with red-blood-cell alloimmunization in the Czech population
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28052334
DOI
10.1111/vox.12478
Knihovny.cz E-zdroje
- Klíčová slova
- HLA, red-blood-cell antigens and antibodies, transfusion medicine (in general),
- MeSH
- alely MeSH
- dospělí MeSH
- erytrocyty imunologie MeSH
- frekvence genu MeSH
- genotyp MeSH
- haplotypy MeSH
- HLA-DQ beta řetězec genetika imunologie MeSH
- HLA-DRB1 řetězec genetika imunologie MeSH
- isoprotilátky krev MeSH
- lidé MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- HLA-DQ beta řetězec MeSH
- HLA-DQB1 antigen MeSH Prohlížeč
- HLA-DRB1 řetězec MeSH
- isoprotilátky MeSH
BACKGROUND AND OBJECTIVES: Alloimmune antibodies against red-blood-cell (RBC) antigens induced in susceptible individuals (responders) by transfusion, pregnancy or transplantation may have serious clinical consequences. The aim of this study was to investigate association of alloimmunization against selected RBC antigens with HLA-Class II. MATERIALS AND METHODS: A total of 230 responders (106 monoresponders and 124 multiresponders) were enrolled into the study. HLA-DRB1 and HLA-DQB1 variants were determined by PCR-SSO and their frequencies compared between the patients (patient subgroups) and 375 ethnically and regionally matched controls. RESULTS: Development of multiple RBC antibodies was associated with HLA-DRB1*15 and HLA-DQB1*06 allelic groups in the patients, with the relationship being particularly apparent in those with anti-C+D antibodies. Furthermore, DRB1*13 and DQB1*06 were more frequent in multiresponders with anti-E+c antibodies and DRB1*03 and DQB1*02 in those with anti-E+Cw. CONCLUSION: For the first time, we confirmed the association of HLA-DRB1*15 with RBC antibody multiresponder status and found HLA-Class II associations for three frequent RBC antibody combinations. Our data support the concept that HLA restriction plays an important role in the response to RBC alloantigens.
Blood Centre University Hospital Ostrava Czech Republic
Department of Haematology and Oncology University Hospital Plzen Czech Republic
Department of Immunology Faculty of Medicine and Dentistry Palacky University Olomouc Czech Republic
Faculty of Medicine Ostrava University Ostrava Czech Republic
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