Stem Cells: Therapeutic Implications in Chemotherapy and Radiotherapy Resistance in Cancer Therapy
Jazyk angličtina Země Spojené arabské emiráty Médium print
Typ dokumentu přehledy, časopisecké články
PubMed
36200212
DOI
10.2174/1574888x17666221003125208
PII: CSCR-EPUB-126724
Knihovny.cz E-zdroje
- Klíčová slova
- Cancer stem cells, biological agents, cancer therapy, chemotherapy, drug resistance, radiotherapy,
- MeSH
- lidé MeSH
- nádorové kmenové buňky metabolismus MeSH
- nádorové mikroprostředí MeSH
- nádory * radioterapie farmakoterapie MeSH
- signální transdukce MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Cancer stem cells (CSCs) are transformed forms of normal stem cells within heterogeneous mixture of cancer cells. These are mainly responsible for the recurrence of cancer after treatment because of their ability to develop resistance against chemo and radiotherapy due to various factors such as activation of signalling pathways important for self-renewal, DNA repair capacity, microenvironment and expression of ABC transporters. Targeting these mechanisms as potential factors can eliminate CSCs, which eventually decreases cancer recurrence. This review focuses on the characteristics of CSCs, their role in the development of resistance to chemotherapy and radiotherapy along with the therapeutic potential targets for successful elimination of CSC population.
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