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MeSH: pyramidové dráhy-patologie

16 záznamů v Medvik Filtry

Kapitola

Hybnost její poruchy

Roth, Jan, 1961-
Autor Autorita ORCID Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN, Praha Psychiatrická klinika 1. LF UK a VFN, Praha
Miler, Michal
Autor Autorita Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN, Praha
Domluvilová, Daniela
Autor Autorita ORCID Psychiatrická klinika 1. LF UK a VFN, Praha

Neuropsychiatrie. 2020 ; () : 115-123.

ISBN 978-80-7345-619-1
Medvik
Zdroj

Klíčová slova
motorická jednotka, míšní reflex,
MeSH
bazální ganglia diagnostické zobrazování patologie MeSH
lidé MeSH
motorické dovednosti fyziologie MeSH
motorické korové centrum fyziologie patologie MeSH
motorické poruchy * klasifikace MeSH
mozkový kmen anatomie a histologie patologie MeSH
periferní nervy anatomie a histologie fyziologie patologie MeSH
pyramidové dráhy fyziologie patologie MeSH
terminologie jako téma MeSH
Check Tag
lidé MeSH
Publikační typ
přehledy MeSH

Článek

Pyramidal system involvement in progressive supranuclear palsy - a clinicopathological correlation

BMC neurology. 2019 ; 19 (1) : 42. [pub] 20190320

BMC Neurol
ISSN 1471-2377
Medvik
Zdroj

BACKGROUND: We aimed to produce a detailed neuropathological analysis of pyramidal motor system pathology and provide its clinical pathological correlation in cases with definite progressive supranuclear palsy (PSP). METHODS: Pyramidal motor system pathologies were analyzed in 18 cases with neuropathologically confirmed PSP. Based on a retrospective clinical analysis, cases were subtyped according to Movement Disorder Society criteria for clinical diagnosis of PSP as probable, possible or suggestive of PSP with Richardson's syndrome (n = 10), PSP with predominant corticobasal syndrome (n = 3), PSP with predominant parkinsonism (n = 3), PSP with predominant speech/language disorder (n = 1), and PSP with progressive gait freezing (n = 1). Clinical manifestations of motor neuron involvement (pseudobulbar or bulbar signs and spasticity) were retrospectively assessed semiquantitatively. Neuropathologically, hyperphosphorylated tau-related pyramidal motor system neuronal, neuritic, and glial pathology using anti-tau AT8 clone immunohistochemistry, was also evaluated. RESULTS: Clinical manifestations of pyramidal motor system involvement were found in patients with different PSP subtypes. A statistically significant higher load of tau pathology was found in the pyramidal system in PSP-Richardson's syndrome compared to other PSP subtypes (p = 0.016); however, there was no significant correlation between pyramidal system tau pathology and related motor clinical symptoms. CONCLUSIONS: Tau pathology in the spinal cord and pyramidal motor system structures is very common in progressive supranuclear palsy and may neuropathologically supplement the distinction between classic Richardson's syndrome from other progressive supranuclear palsy subtypes.

MeSH
imunohistochemie MeSH
lidé středního věku MeSH
lidé MeSH
mozková kůra patologie MeSH
parkinsonské poruchy diagnóza patologie MeSH
pohybové poruchy diagnóza patologie MeSH
progresivní supranukleární obrna diagnóza patologie MeSH
proteiny tau metabolismus MeSH
pyramidové dráhy patologie MeSH
retrospektivní studie MeSH
senioři nad 80 let MeSH
senioři MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH

Článek

Ovlivnění výsledku traktografie pyramidové dráhy volbou oblasti zájmu trasování – kazuistika
[Effect of the region of interest choice on the results of pyramidal tract representation by diffusion tensor imaging – a case report]

Česká a slovenská neurologie a neurochirurgie. 2015 ; 78 (3) : 354-358.

ISSN 1210-7859
Medvik
Zdroj

V krátkém sdělení dokumentujeme u pacienta s gliomem postihujícím precentrální gyrus relativitu výsledku zobrazení pyramidové dráhy pomocí DW traktografie a diskutujeme o faktorech, které mohou ovlivnit zobrazení dráhy. Dle našeho názoru se v dostupné literatuře nevěnuje dostatečná pozornost volbě oblasti zájmu trasování, přičemž právě ta je klíčovým determinantem výsledku.

In our short report, we show the relative nature of pyramidal tract representation using Diffusion Tensor Imaging in a patient with a precentral gyrus glioma and we discuss the factors that may affect tract reconstruction. We believe that, so far, inadequate attention has been paid in the published literature to the region of interest selection even though this is the key determinant of the imaging outcome. Key words: glioma – navigation – tractography – electric cortical stimulation The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Článek

Oligodendroglial response in the spinal cord in TDP-43 proteinopathy with motor neuron involvement

Neuro-degenerative diseases. 2014 ; 14 (3) : 117-124. [pub] 20140805

Neurodegener Dis
ISSN 1660-2862
Medvik
Zdroj

BACKGROUND: TDP-43 proteinopathies represent a spectrum of neurodegenerative disorders. Variable clinical presentations including frontotemporal dementia, amyotrophic lateral sclerosis (ALS) and mixed forms are associated with the spatial heterogeneity of the TDP-43 pathology. Recent studies have emphasized the role of oligodendrocytes in the pathogenesis of ALS. OBJECTIVE: To evaluate whether TDP-43 proteinopathies are associated with an oligodendroglial response. METHODS: We performed a study on 7 controls and 10 diseased patients with spinal cord involvement. Using the oligodendroglia-specific antibody TPPP/p25, we assessed oligodendrocyte density in the lateral corticospinal tracts (LCSs) along with the presence of perineuronal oligodendrocytes (PNOGs) in the anterior horns. We performed a densitometry of myelin basic protein (MBP) immunoreactivity. The numbers of TDP-43 and p62 immunoreactive inclusions were counted in both the LCSs and the anterior horns. RESULTS: Double immunolabeling confirmed that oligodendrocytes harbor TDP-43 inclusions. In the LCSs, MBP density, but not the number of oligodendrocytes, was decreased in the diseased group. However, oligodendrocyte counts in the LCS correlated positively, and the density of MBP inversely, with the number of neuronal inclusions in the anterior horn, suggestive of a compensatory response of oligodendrocytes. The number of neurons with PNOGs correlated with the amount of inclusions. CONCLUSION: Our study further emphasizes the importance of oligodendroglia in the pathogenesis of TDP-43 proteinopathies with spinal cord involvement.

Článek

Is intraoperative diffusion tensor imaging at 3.0T comparable to subcortical corticospinal tract mapping

Neurosurgery. 2013 ; 73 (5) : 797-807; discussion 806-7.

ISSN 1524-4040
Medvik
Zdroj

BACKGROUND: Primary brain tumors in motor eloquent areas are associated with high-risk surgical procedures because of potentially permanent and often disabling motor deficits. Intraoperative primary motor cortex mapping and corticospinal tract (CST) monitoring are well-developed and reliable techniques. Imaging of the CST by diffusion tensor tractography (DTT) is also feasible. OBJECTIVE: To evaluate the practical value of 3.0T intraoperative MRI (iMRI) with intraoperative DTT (iDTT) in surgery close to the CST, and to compare high-field iDTT with intraoperative neurophysiological CST mapping during glioma and metastasis resection in a routine setting. METHODS: Twenty-five patients (13 males, 12 females, median 47 years) were enrolled prospectively from June 2010 to June 2012. Patients were included if they had a solitary supratentorial intracerebral lesion compressing or infiltrating the CST according to preoperative MRI. Subcortical CST mapping was performed by monopolar (cathodal) stimulation (500 Hz, 400 μs, 5 pulses). CST DTT was made both at preoperative and intraoperative 3.0T MRI. Subcortical motor-evoked potential threshold current and probe-CST distance were recorded at 155 points before and at 103 points after iMRI. Current-distance correlations were performed both for pre-iMRI and for post-iMRI data. RESULTS: The correlation coefficient pre-iMRI was R = 0.470 (P < .001); post-iMRI, the correlation coefficient was R = 0.338 (P < .001). MRI radical resection was achieved in 17 patients (68%), subtotal in 5 (24%), and partial in 3 (12%). Postoperative paresis developed in 8 patients (32%); the paresis was permanent in 1 case (4%). CONCLUSION: The linear current-distance correlation was found both in pre-iMRI and in post-iMRI data. Intraoperative image distortion appeared in 36%. Neurophysiological subcortical mapping remains superior to DTT. Combining these 2 methods in selected cases can help increase the safety of tumor resection close to the CST.

Článek

The use of diffusion tensor images of the corticospinal tract in intrinsic brain tumor surgery: a comparison with direct subcortical stimulation

Neurosurgery. 2012 ; 71 (2) : 331-340; discussion 340.

ISSN 1524-4040
Medvik
Zdroj

BACKGROUND: Diffusion tensor imaging (DTI) is now widely used in neurosurgery to preoperatively delineate the course of the pyramidal tract. OBJECTIVE: To evaluate the accuracy of the method by comparison with subcortical electrical stimulation and to evaluate the influence of the distance of the pyramidal tract from the tumor on the resection extent and postoperative clinical deficits. METHODS: A diffusion tensor imaging depiction of the pyramidal tract was used in preoperative planning and intraoperative navigation in 72 cases. In 36 cases, subcortical electrical stimulation was used during the resection. The preoperative tumor-to-tract distance was compared with the stimulation result, the extent of resection, and the short-term postoperative course. RESULTS: A significant nonlinear relationship between the tract-to-tumor distance and the probability of a motor response to subcortical stimulation was observed. The largest preoperatively measured tumor-to-tract distance with a positive stimulation result was 8 mm. Moreover, we observed a trend toward transient postoperative motor deterioration in patients with tumors close to the pyramidal tract. Resection extent was not significantly affected by the tumor-to-tract distance. CONCLUSION: Despite methodological obstacles, reasonable accuracy of the diffusion tensor imaging reconstructions of the pyramidal tracts was confirmed by our study. The occurrence of transient postoperative motor deterioration is higher in patients with tumors located close to the pyramidal tract.

MeSH
difuzní magnetická rezonance metody MeSH
elektrodiagnostika metody MeSH
hluboká mozková stimulace metody MeSH
lidé středního věku MeSH
lidé MeSH
nádory mozku patologie chirurgie MeSH
předoperační péče metody MeSH
pyramidové dráhy patologie MeSH
reprodukovatelnost výsledků MeSH
senzitivita a specificita MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
klinické zkoušky kontrolované MeSH
práce podpořená grantem MeSH
srovnávací studie MeSH

Článek

Identification of the large descending tracts using diffusion tensor imaging in Chiari III malformation

Child's nervous system. 2010 ; 26 (7) : 867-870. [pub] 20100423

Childs Nerv Syst
ISSN 1433-0350
Medvik
Zdroj

INTRODUCTION: The paper focuses on the use of diffusion tensor imaging (DTI) in the evaluation of one case of Chiari III malformation. CASE REPORT: In the case discussed, DTI was used to delineate the position of large descending tracts within the malformation and the reconstructed images were used to plan the surgical procedure. DISCUSSION: The clinical and imaging findings, the technical aspects of the DTI fiber tract reconstruction and the outcome are summarized.