We examined the protective effect of radon inhalation on streptozotocin (STZ)-induced type-1 diabetes in mice. Mice inhaled radon at concentrations of 1000, 2500, and 5500 Bq/m3 for 24 hours before STZ administration. STZ administration induced characteristics of type-1 diabetes such as hyperglycemia and hypoinsulinemia; however, radon inhalation at doses of 1000 and 5500 Bq/m3 significantly suppressed the elevation of blood glucose in diabetic mice. Serum insulin was significantly higher in mice pre-treated with radon at a dose of 1000 Bq/m3 than in mice treated with a sham. In addition, superoxide dismutase activities and total glutathione contents were significantly higher and lipid peroxide was significantly lower in mice pre-treated with radon at doses of 1000 and 5500 Bq/m3 than in mice treated with a sham. These results were consistent with the result that radon inhalation at 1000 and 5500 Bq/m3 suppressed hyperglycemia. These findings suggested that radon inhalation suppressed STZ-induced type-1 diabetes through the enhancement of antioxidative functions in the pancreas.
- MeSH
- antioxidancia aplikace a dávkování MeSH
- aplikace inhalační MeSH
- biologické markery krev MeSH
- časové faktory MeSH
- diabetes mellitus 1. typu krev chemicky indukované patologie prevence a kontrola MeSH
- experimentální diabetes mellitus krev chemicky indukované patologie prevence a kontrola MeSH
- glutathion metabolismus MeSH
- hypoglykemika aplikace a dávkování MeSH
- inzulin krev MeSH
- krevní glukóza účinky léků metabolismus MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- pankreas účinky léků metabolismus patologie MeSH
- plyny MeSH
- radon aplikace a dávkování MeSH
- streptozocin * MeSH
- superoxiddismutasa metabolismus MeSH
- tělesná hmotnost účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- balneologie metody MeSH
- lázně MeSH
- lidé MeSH
- radon aplikace a dávkování terapeutické užití MeSH
- Check Tag
- lidé MeSH