Sulfamethoxazole (SMX) and its residues exhibit high environmental persistence due to their resistance to conventional degradation processes. The bacterial strain Kocuria rhizophila SA117, isolated from polluted soils, was characterized biochemically, phylogenetically, and -omically. Herein, we describe a complete degradation pathway for SMX and determine two putative pathways: cleavage of the benzene ring and the degradation of the substituted isoxazole, leading to the formation of non-toxic Krebs cycle metabolites. Based on molecular structures containing 13C6-labeled carbons and 2H3 atoms, thirty metabolites were identified by high-resolution tandem mass spectrometry. Genomic and proteomic analysis of strain SA117 revealed its ability to perform a wide range of metabolic activities under sulfamethoxazole selective pressure. These activities include energy and sulfur metabolism, adaptation to stress conditions, and catabolism of aromatic compounds. This study has greatly enhanced the understanding of microbial sulfonamide degradation and highlighted the potential of the bacterium Kocuria in remediation strategies.

• Klíčová slova
• Biodegradation, Genome sequencing, Metabolic profiling, Proteomics, Sulfonamide,
• MeSH
• biodegradace MeSH
• fylogeneze MeSH
• katalýza MeSH
• metabolické sítě a dráhy * MeSH
• Micrococcaceae * metabolismus   genetika   MeSH
• proteomika MeSH
• sulfamethoxazol * metabolismus   MeSH
• tandemová hmotnostní spektrometrie MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• sulfamethoxazol * MeSH

INTRODUCTION: The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically in the last few years, with different options being available, and with no data comparing these new systemic therapies. Therefore, the value of real-world outcomes (RWO) becomes of great interest to understand the effectiveness of these treatments. Here we analyze the outcome of metastatic RCC patients treated with first-line cabozantinib in a retrospective cohort from the Czech Republic and Poland METHODS: Patients with metastatic RCC treated with first-line cabozantinib in the Czech Republic and Poland were included in a retrospective fashion. Data were collected regarding progression-free survival (PFS), overall survival (OS), response rate and toxicity, with a focus in several subgroups of interest. RESULTS: We identified 146 patients, the majority of them (80.8%) with clear cell RCC (ccRCC). The median OS was 14.7 months, and the median PFS 8.2 months, with a response rate of 30.3%. CTCAE v3.0 grade 3+4 toxicity was presented in 34.2% of patients. The efficacy of Cabozantinib was maintained regardless of histologic subtype and the presence of sarcomatoid component, although PFS and OS data were numerically better for nonclear cell RCC. Bone and liver metastases were confirmed as independent factor for poor survival in the multivariate analysis. CONCLUSIONS: In our series, Cabozantinib demonstrated its activity in RCC patients in a RWO setting. Our data can be considered comparable with what has been seen in randomised clinical trials, considering the inherent bias present in RWO studies.

• Klíčová slova
• First-line therapy, Real world outcomes, Renal cancer, Tyrosine kinase inhibitors,
• MeSH
• anilidy * terapeutické užití   škodlivé účinky   aplikace a dávkování   MeSH
• doba přežití bez progrese choroby MeSH
• dospělí MeSH
• inhibitory proteinkinas * terapeutické užití   škodlivé účinky   MeSH
• karcinom z renálních buněk * farmakoterapie   mortalita   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory ledvin * farmakoterapie   patologie   mortalita   MeSH
• pyridiny * terapeutické užití   škodlivé účinky   aplikace a dávkování   MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH
• Polsko MeSH
• Názvy látek
• anilidy * MeSH
• cabozantinib MeSH Prohlížeč
• inhibitory proteinkinas * MeSH
• pyridiny * MeSH

BACKGROUND: The optimal first-line therapy for metastatic renal cell carcinoma (mRCC) remains uncertain, despite recent advancements in immune-based combinations. This retrospective study compares the effectiveness of pembrolizumab plus axitinib (PA) and nivolumab plus cabozantinib (NC) as first-line treatments for mRCC in a real-world setting. METHODS: Patient data were collected from 55 centers across 16 countries, encompassing individuals diagnosed with mRCC receiving first-line treatment with PA or NC between January 2016 and October 2023. Clinical and tumor features and treatment responses were recorded. The primary endpoints were overall response rate (ORR), overall survival (OS), progression-free survival (PFS), and time to second progression. Statistical analyses included Kaplan-Meier survival estimates, Cox proportional hazard models, and chi-square tests. RESULTS: A total of 760 patients with a median age of 64 years (range, 29-88) were included. Of them, 607 received PA, and only 153 NC. In the overall study population, ORR was 59% for and 49% for PA. Median OS was 55.7 months and not reached (NR) for PA and NC, respectively (P = .51), while median PFS was longer with NC (27.6 months) than for PA (16.2 months, P = .003). Subgroup analysis suggested a PFS benefits for NC in male, younger patients, intermediate risk group, clear cell histology, and lung involvement, as well as ORR favored NC in good risk patients. Multivariate analysis identified first-line therapy as a significant factor associated with PFS. CONCLUSIONS: In this certainly biased retrospective comparison, NC demonstrated superior ORR and longer PFS compared to PA in mRCC. These findings underscore the importance of considering individual patient characteristics and risk profiles when selecting first-line therapy for mRCC.

• Klíčová slova
• ARON-1 study, Axitinib plus pembrolizumab, Cabozantinib plus nivolumab, Immune-oncology combinations,
• MeSH
• anilidy * terapeutické užití   farmakologie   aplikace a dávkování   MeSH
• axitinib * terapeutické užití   farmakologie   aplikace a dávkování   MeSH
• dospělí MeSH
• humanizované monoklonální protilátky * terapeutické užití   farmakologie   aplikace a dávkování   MeSH
• karcinom z renálních buněk * farmakoterapie   mortalita   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory ledvin * farmakoterapie   patologie   mortalita   MeSH
• nivolumab * terapeutické užití   farmakologie   aplikace a dávkování   MeSH
• protokoly protinádorové kombinované chemoterapie * terapeutické užití   MeSH
• pyridiny terapeutické užití   MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• srovnávací studie MeSH
• Názvy látek
• anilidy * MeSH
• axitinib * MeSH
• cabozantinib MeSH Prohlížeč
• humanizované monoklonální protilátky * MeSH
• nivolumab * MeSH
• pembrolizumab MeSH Prohlížeč
• pyridiny MeSH

Manganese-oxidizing bacteria (MnOB) and biogenic manganese oxides (BioMnOx) play key roles in the breakdown of organic matter (including pollutants) in water and soil environments. The degradation of some organic compounds (such as sulfonamides selected in this study) by BioMnOx in the presence of active MnOB is poorly understood. Thus far, it has been shown that the transformation of sulfonamides by either BioMnOx or MnOB (but thus far not studied in a binary system) can be modulated using naturally occurring redox mediators, such as humic substances, leading to the formation of coupling products of unknown stability. The co-occurrence of sulfonamides, MnOB, BioMnOx, and humic constituents is pertinent to many natural and engineered settings. This study used syringaldehyde, which is a model humic constituent, to investigate the nature of modulation in a binary system of BioMnOx and MnOB for the first time. The MnOB strain Pseudomonas putida MnB6 was cultivated and used in batch degradation tests. Initial tests with eight sulfonamides showed comparably poor degradation. In the next step of this study, sulfamethoxazole (SMX) and two SMX submoieties (sulfanilamide (SNM) and 3-amino-5-methylisoxazole (ISX)) were examined. After 48-60 hours in active cultures with BioMnOx, the degradation of all the three substances was negligible. However, syringaldehyde increased the degradation efficiency by 26% for SMX, 58% for SNM, and 27% for ISX. The active culture and BioMnOx synergistically improved degradation, highlighting the importance of BioMnOx regeneration. Removal was partially reversible (10-30%) owing to the retransformation of the reaction products into parent compounds, which was induced by syringaldehyde depletion. Unstable reaction products were conjugates of SMX, SNM, and ISX with syringaldehyde or its oxidation product DMBQ (2,6-dimethoxy-1,4-benzoquinone). This deconjugation likely contributes to process reversibility, potentially negatively impacting the environment and the safety of water and wastewater treatment systems.

• MeSH
• Bacteria * metabolismus   MeSH
• biodegradace MeSH
• chemické látky znečišťující vodu * metabolismus   MeSH
• huminové látky * analýza   MeSH
• mangan * metabolismus   MeSH
• oxidace-redukce MeSH
• oxidy * metabolismus   MeSH
• Pseudomonas putida * metabolismus   MeSH
• sloučeniny manganu * metabolismus   MeSH
• sulfamethoxazol * metabolismus   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chemické látky znečišťující vodu * MeSH
• huminové látky * MeSH
• mangan * MeSH
• manganese oxide MeSH Prohlížeč
• oxidy * MeSH
• sloučeniny manganu * MeSH
• sulfamethoxazol * MeSH

This study introduces a novel method for the quantification of malachite green (MG), a pervasive cationic dye, in surface water by synergizing multiphase electroextraction (MPEE) with digital image analysis (DIA) and partial least square discriminant analysis. Aimed at addressing the limitations of conventional DIA methods in terms of quantitation limits and selectivity, this study achieves a significant breakthrough in the preconcentration of MG using magnesium silicate as a novel sorbent. Demonstrating exceptional processing efficiency, the method allows for the analysis of 10 samples within 20 min, exhibiting remarkable sensitivity and specificity (over 0.95 and 0.90, respectively) across 156 samples in both training and test sets. Notably, the method detects MG at low concentrations (0.2 µg L-1) in complex matrices, highlighting its potential for broader application in environmental monitoring. This approach not only underscores the method's cost-effectiveness and simplicity but also its precision, making it a valuable tool for the preliminary testing of MG in surface waters. This study underscores the synergy among MPEE, DIA, and chemometric tools, presenting a cost-efficient and reliable alternative for the sensitive detection of water contaminants.

• Klíčová slova
• cationic dyes, complex matrices, free liquid membrane, water contaminant,
• MeSH
• chemické látky znečišťující vodu * analýza   izolace a purifikace   MeSH
• chemometrika metody   MeSH
• diskriminační analýza MeSH
• limita detekce MeSH
• lineární modely MeSH
• metoda nejmenších čtverců MeSH
• počítačové zpracování obrazu * metody   MeSH
• reprodukovatelnost výsledků MeSH
• rosanilinová barviva * analýza   izolace a purifikace   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chemické látky znečišťující vodu * MeSH
• malachite green MeSH Prohlížeč
• rosanilinová barviva * MeSH

Nowadays, most of the newly developed active pharmaceutical ingredients (APIs) consist of cohesive particles with a mean particle size of <100μm, a wide particle size distribution (PSD) and a tendency to agglomerate, therefore they are difficult to handle in continuous manufacturing (CM) lines. The current paper focuses on the impact of various glidants on the bulk properties of difficult-to-handle APIs. Three challenging powders were included: two extremely cohesive APIs (acetaminophen micronized (APAPμ) and metoprolol tartrate (MPT)) which previously have shown processing issues during different stages of the continuous direct compression (CDC)-line and a spray dried placebo (SD) powder containing hydroxypropylmethyl cellulose (HPMC), known for its sub-optimal flow with a high specific surface area (SSA) and low density. Four flow-enhancing excipients were used: a hydrophilic (Aerosil® 200) and hydrophobic (Aerosil® R972) fumed silica grade, a mesoporous silica grade (Syloid® 244FP), and a calcium phosphate excipient (TRI-CAFOS® 200-7). The APIs and binary API/glidant blends (varied between 0.5-2.75 w/w%) were characterized for their bulk properties relevant for CDC. The results indicated that optimizing different bulk parameters (e.g., density, flow, compressibility..) of an API required varying weight percentages of the glidant (e.g., different surface area coverage (SAC)) depending on the APIs. Moreover, even at similar SAC, the impact of the glidant on the bulk characteristic of the APIs depended on the glidant type properties. While nano-sized silicon dioxide were effective for improving the flowability of a powder, other glidants (mesoporous silica and tricalcium phosphate (TCP)) showed also promise as alternatives. Additionally, an excess of glidant, referred to as oversilication, negatively impacted some bulk parameters, but other characteristics were unaffected. Finally, to determine the appropriate concentration of the different classes of glidants, SAC calculations, an understanding of the glidant's working mechanism, and knowledge about the API's characteristics (i.e., morphology, compressibility, flowability, aeration, density, and wall friction) are required. This study confirmed the necessity of including various material characterization techniques to assess the impact of glidants on the bulk characteristics of APIs.

• Klíčová slova
• Continuous manufacturing, Flow enhancers, Glidant, Material characterization, Rheological properties,
• MeSH
• deriváty hypromelózy chemie   MeSH
• fosforečnany vápenaté chemie   MeSH
• metoprolol * chemie   MeSH
• nerozplněné léky MeSH
• oxid křemičitý chemie   MeSH
• paracetamol * chemie   MeSH
• pomocné látky * chemie   MeSH
• prášky, zásypy, pudry chemie   MeSH
• příprava léků metody   MeSH
• reologie MeSH
• velikost částic MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• deriváty hypromelózy MeSH
• fosforečnany vápenaté MeSH
• metoprolol * MeSH
• nerozplněné léky MeSH
• oxid křemičitý MeSH
• paracetamol * MeSH
• pomocné látky * MeSH
• prášky, zásypy, pudry MeSH

A series of eighteen new 2-trifluoromethylcinnamanilides (1a-r) were synthesized by microwave synthesis and investigated for their antimycobacterial and antimalarial activities, along with the complementary (2E)-3-[3-(trifluoromethyl)phenyl]-N-arylprop-2-enanilides (2a-r) and (2E)-3-[4-(trifluoromethyl)phenyl]-N-arylprop-2-enanilides (3a-r) prepared earlier. All the compounds were evaluated in vitro against Mycobacterium smegmatis ATCC 700084 and a chloroquine-sensitive strain of Plasmodium falciparum 3D7/MRA-102. The most active compounds against M. smegmatis (MIC values in the range of 1.17-11.1 µM, more effective than rifampicin) were anilides substituted by 3,5-CF3 (1q, 2q, 3q), 4-OCF3 (1k), and 4-CF3 (1j, 2j). The most effective agents against P. falciparum (IC50 values in the range of 0.32-4.5 µM, comparable to chloroquine) were anilides substituted by 3,5-CF3 (1q, 2q, 3q), 2-Br-4-OCF3 (1r), 4-CF3 (1j, 3j), 4-F (2d), 4-Cl (2g), 2-Cl (1e, 2e). A preliminary in vitro cytotoxicity screening was assessed using human leukemic cell lines and human dermal fibroblasts, revealing the toxic effect of 3,5-CF3 substituted anilides. On the other hand, the other investigated agents showed insignificant cytotoxic effects. Stability assays using rat liver microsomes demonstrated that compounds 1r (R = 2-Br-4-OCF3) and 1q (R = 3,5-CF3) are neither metabolized nor affect cytochrome P450 metabolizing capacity in vitro. Furthermore, complex in silico studies were performed - a combined approach (docking/MD simulations/QTAIM calculations) helped to define the molecular interactions that were applied during the binding of active agents and the subsequent inhibition of their molecular targets - InhA (activity against M. smegmatis) and arginase (activity against P. falciparum). In conclusion, promising active agents with dual antimycobacterial and antimalarial effects were identified.

• Klíčová slova
• Cinnamanilides, Cytotoxicity, Lipophilicity, M. smegmatis, Molecular modeling, P. falciparum, QTAIM calculations,
• MeSH
• anilidy farmakologie   chemie   chemická syntéza   MeSH
• antibakteriální látky farmakologie   chemie   chemická syntéza   MeSH
• antimalarika * farmakologie   chemie   chemická syntéza   MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• mikrobiální testy citlivosti MeSH
• molekulární struktura MeSH
• Mycobacterium smegmatis * účinky léků   MeSH
• parazitické testy citlivosti MeSH
• Plasmodium falciparum * účinky léků   MeSH
• simulace molekulového dockingu MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• vztahy mezi strukturou a aktivitou MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anilidy MeSH
• antibakteriální látky MeSH
• antimalarika * MeSH

The forskolin-induced swelling assay (FIS) in patient-derived intestinal organoids (PDIOs), used to determine in vitro responsiveness to elexacaftor/tezacaftor/ivacaftor (ETI), showed variability in swelling among PDIOs obtained from people with CF (pwCF) carrying the same F508del/F508del CFTR genotype. We aimed to characterise the effect of ETI on the transcriptional activity of PDIOs-derived cells to understand the intracellular processes triggered by ETI and the differences in treatment response. Six high- and six low-responding PDIOs to ETI, derived from F508del/F508del pwCF, were incubated with or without ETI for 2 to 6 h. Gene expression was assessed using 3'-mRNA sequencing and modelled using negative binomial models. Incubation with ETI resulted in a significant upregulation of several biological processes: mostly related to chemokines and signalling, chemotaxis, and tissue development processes. No changes were observed in abundance of the CFTR transcripts or in CFTR-related gene sets and pathways. The genes and pathways associated with ETI did not overlap with those whose expression changed with time only. PDIOs with a high FIS response did not significantly differ in any interpretable gene from the FIS-low organoids. The changes in the PDIOs gene expression upon the exposure to ETI cannot explain differences in the magnitude of PDIOs FIS-measured response to ETI. In conclusion, on incubation with ETI, genes of the CFTR-related pathways do not change their transcriptional activity; instead, overexpression was observed in genes of inflammatory-like cytokine response and receptor activation pathways.

• Klíčová slova
• Cystic fibrosis, Differential expression, Elexacaftor, Intestinal organoid, Ivacaftor, Tezacaftor,
• MeSH
• aktivátory chloridových kanálů farmakologie   MeSH
• aminofenoly * farmakologie   MeSH
• benzodioxoly * farmakologie   MeSH
• chinolony * farmakologie   MeSH
• cystická fibróza * genetika   farmakoterapie   MeSH
• fixní kombinace léků MeSH
• indoly * farmakologie   MeSH
• lidé MeSH
• organoidy * účinky léků   metabolismus   MeSH
• protein CFTR genetika   MeSH
• pyridiny * farmakologie   MeSH
• pyrroly * farmakologie   MeSH
• stanovení celkové genové exprese MeSH
• thiofeny farmakologie   MeSH
• transkriptom MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• aktivátory chloridových kanálů MeSH
• aminofenoly * MeSH
• benzodioxoly * MeSH
• chinoliny MeSH
• chinolony * MeSH
• elexacaftor, ivacaftor, tezacaftor drug combination MeSH Prohlížeč
• elexacaftor MeSH Prohlížeč
• fixní kombinace léků MeSH
• indoly * MeSH
• ivacaftor MeSH Prohlížeč
• protein CFTR MeSH
• pyrazoly MeSH
• pyridiny * MeSH
• pyrrolidiny MeSH
• pyrroly * MeSH
• tezacaftor MeSH Prohlížeč
• thiofeny MeSH

BACKGROUND: Celosia argentea is a widely recognized plant for its ornamental qualities and therapeutic uses in traditional medicine. As demand for such multipurpose plants grows, enhancing its phenotypic and physiological traits could further expand its commercial potential. Polyploidization, particularly through chemical treatments like oryzalin, offers a method to induce genetic variation and potentially improve desirable traits in plants. RESULTS: Tetraploid (2n = 4×= 36) nodal segments of C. argentea were treated with oryzalin under in vitro conditions, resulting in successful induction of octoploidy (2n = 8×= 72). Flow cytometry and chromosome counting confirmed polyploidization, with the highest induction rate achieved using 40 µM oryzalin for 24 h. Comparative analyses between octoploid and tetraploid plants revealed significant differences in morphological traits, including increased stem and leaf thickness, larger leaf area, inflorescence characteristics and more compact growth in the octoploids. Additionally, octoploids exhibited enhanced chlorophyll content and altered photosynthetic characteristics, along with notable changes in stomatal size and density. Ploidy stability was maintained across generations, ensuring the heritability of the induced traits. CONCLUSIONS: In vitro polyploidization in C. argentea led to significant phenotypic and physiological improvements, demonstrating its potential for application in ornamental horticulture and plant breeding. This research contributes to the understanding of the impact of in vitro polyploidization on plant development, offering insights for the commercial cultivation and enhancement of C. argentea. CLINICAL TRIAL NUMBER: Not applicable.

• Klíčová slova
• Chromosome doubling, Cockscomb, Crop improvement, Offspring stability, Oryzalin, Polyploid induction, Polyploidization,
• MeSH
• Celosia * genetika   MeSH
• chlorofyl metabolismus   MeSH
• dinitrobenzeny farmakologie   MeSH
• fenotyp MeSH
• fotosyntéza * MeSH
• listy rostlin genetika   růst a vývoj   fyziologie   MeSH
• polyploidie * MeSH
• sulfanilamidy MeSH
• tetraploidie * MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• chlorofyl MeSH
• dinitrobenzeny MeSH
• oryzalin MeSH Prohlížeč
• sulfanilamidy MeSH

Exposure to aromatic amines may occur via tobacco smoke, hair dyes or tattoo inks, but also in the workplace during certain manufacturing processes. As some aromatic amines are known or suspected carcinogens, human biomonitoring (HBM) is essential to assess their exposure. Aromatic amines were among the selected chemicals in HBM4EU, a European-wide project to harmonise and advance HBM within 30 European countries. For this purpose, the analytical comparability and accuracy of participating laboratories were assessed by a QA/QC programme comprising interlaboratory comparison investigations (ICIs) and external quality assurance schemes (EQUASs). This paper presents the evaluation process and discusses the results of three ICI/EQUAS rounds for the determination of aromatic amines in urine conducted in 2019 and 2020. The final evaluation included ten participants which analysed the following six targeted aromatic amines over three rounds: aniline, ortho-toluidine (TOL), 4,4'-methylenedianiline (MDA), 4,4'-methylenebis(2-chloroaniline) (MOCA), 2,4-diaminotoluene (2,4-TDA), and 2,6-diaminotoluene (2,6-TDA). Most participants achieved satisfactory and highly comparable results, although low quantification limits were required to quantify the parameters at the level of exposure in the general population. Hydrolysis of the sample followed by liquid-liquid extraction and subsequent analysis of the derivatised analytes by means of GC-MS/MS were preferred for the sensitive and precise determination of aromatic amines in urine. This QA/QC programme succeeded in establishing a network of laboratories with high analytical comparability and accuracy for the analysis of aromatic amines in Europe.

• MeSH
• aminy * moč   analýza   MeSH
• aniliny moč   MeSH
• biologický monitoring * metody   MeSH
• fenylendiaminy MeSH
• laboratoře normy   MeSH
• lidé MeSH
• methylenbis(chloranilin) MeSH
• řízení kvality MeSH
• tandemová hmotnostní spektrometrie metody   MeSH
• toluidiny MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Geografické názvy
• Evropa MeSH
• Názvy látek
• 2-toluidine MeSH Prohlížeč
• 2,4-diaminotoluene MeSH Prohlížeč
• 4,4'-diaminodiphenylmethane MeSH Prohlížeč
• aminy * MeSH
• aniline MeSH Prohlížeč
• aniliny MeSH
• fenylendiaminy MeSH
• methylenbis(chloranilin) MeSH
• toluidiny MeSH