BACKGROUND: The aim of the study was to determine the acute effects of salmon calcitonin (sCT) on bone resorption as assessed by plasma type 1 collagen cross-linked C-telopeptide (CTX). In addition, the plasma aminoterminal propeptide of type I procollagen (PINP) and osteocalcin (OC) were evaluated as markers of bone formation. METHODS: In six healthy young women, after overnight fasting, single subcutaneous doses of 2, 10 and 50 IU as well as a nasal dose of 200 IU of sCT were administered consecutively with a 1-week washout period. During the control period, no drug was given. Blood samples were drawn at 0700 a.m. (baseline) and throughout the 9-h fasting period. RESULTS: Both intranasal and subcutaneous sCT resulted in a significant reduction in plasma CTX by 50-60% as early as within 1 h. The plasma CTX showed a dose-dependent decrease over a dosage range of 2, 10 and 50 IU after subcutaneous administration of sCT. No significant difference was observed between the areas under curves (AUC) for plasma CTX following intranasal and subcutaneous administration of 200 and 2 IU of sCT, respectively. Synthesis of types I collagen remained unaffected by the dose of 50 IU of subcutaneously administered sCT when the acute effects were considered. CONCLUSIONS: Plasma CTX is a sensitive marker in detecting acute changes of bone resorption after sCT administration.

• MeSH
• biologické markery krev   MeSH
• časové faktory MeSH
• dospělí MeSH
• kalcitonin aplikace a dávkování   farmakologie   MeSH
• kolagen typu I MeSH
• kolagen krev   MeSH
• kostní denzita účinky léků   MeSH
• lidé MeSH
• osteokalcin krev   MeSH
• parathormon krev   MeSH
• peptidové fragmenty krev   MeSH
• peptidy krev   MeSH
• prokolagen krev   MeSH
• resorpce kosti farmakoterapie   MeSH
• vápník krev   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• biologické markery MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kalcitonin MeSH
• kolagen typu I MeSH
• kolagen MeSH
• osteokalcin MeSH
• parathormon MeSH
• peptidové fragmenty MeSH
• peptidy MeSH
• procollagen Type I N-terminal peptide MeSH Prohlížeč
• prokolagen MeSH
• salmon calcitonin MeSH Prohlížeč
• vápník MeSH

OBJECTIVES: To analyze the predictive value of cardiac collagen metabolism "in vivo" in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). DESIGN: Forty-five patients (age 66 +/- 8.27) underwent biochemical analysis for cardiac collagen metabolism (groups A, B and C); 30 patients with their first MI were treated with successful PCI (group A; n = 30), group B (n = 5) were MI patients with unsuccessful PCI. Group C were patients without MI (n = 10), they underwent elective diagnostic coronary angiography only. The collagen metabolism was analyzed in acute and subacute MI phases by using serum blood markers: the carboxy-terminal propeptide of type I procollagen (PICP), amino-terminal propeptide of type III procollagen (PIIINP) and carboxy-terminal telopeptide of type I collagen (ICTP). Furthermore, the ejection fraction (EF) and left ventricular end-diastolic volume maximal changes in the course of 6 months were measured by echocardiography. RESULTS: A significant increase of both PICP and PIIINP on day 4 following MI was detected. Furthermore, PICP and PIIINP level assessed on the 30th day was significantly higher in the PCI unsuccessful group versus successful group. PICP level on day 4 above 110 microg/l and PIIINP level above 4 microg/l was significantly often found in the subgroup of patients with the EF improvement less than 10% or worsening and with significant left ventricular dilatation during 6 months follow-up. Cardiac catheterization itself does not affect collagen metabolism. CONCLUSION: We concluded that collagen metabolism markers enable to study in vivo the MI healing and to predict left ventricular functional and volume changes.

• MeSH
• biologické markery krev   metabolismus   MeSH
• časové faktory MeSH
• echokardiografie MeSH
• funkce levé komory srdeční MeSH
• infarkt myokardu metabolismus   MeSH
• kolagen typu I MeSH
• kolagen metabolismus   MeSH
• lidé středního věku MeSH
• lidé MeSH
• peptidové fragmenty krev   metabolismus   MeSH
• peptidy MeSH
• prokolagen krev   metabolismus   MeSH
• remodelace komor fyziologie   MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• biologické markery MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kolagen typu I MeSH
• kolagen MeSH
• peptidové fragmenty MeSH
• peptidy MeSH
• procollagen type I carboxy terminal peptide MeSH Prohlížeč
• procollagen Type III-N-terminal peptide MeSH Prohlížeč
• prokolagen MeSH

Lysine hydroxylation of type I collagen telopeptides varies from tissue to tissue, and these distinct hydroxylation patterns modulate collagen cross-linking to generate a unique extracellular matrix. Abnormalities in these patterns contribute to pathologies that include osteogenesis imperfecta (OI), fibrosis, and cancer. Telopeptide procollagen modifications are carried out by lysyl hydroxylase 2 (LH2); however, little is known regarding how this enzyme regulates hydroxylation patterns. We identified an ER complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. Our findings show that FKBP65 and HSP47 modulate the activity of LH2 to either favor or repress its activity. BiP was also identified as a member of the complex, playing a role in enhancing the formation of the complex. This newly identified ER chaperone complex contributes to our understanding of how LH2 regulates lysyl hydroxylation of type I collagen C-telopeptides to affect the quality of connective tissues. © 2017 American Society for Bone and Mineral Research.

• MeSH
• biologické modely MeSH
• buněčné linie MeSH
• chaperon endoplazmatického retikula BiP MeSH
• hmotnostní spektrometrie MeSH
• hydroxylace MeSH
• kolagen typu I metabolismus   MeSH
• lidé MeSH
• lysin metabolismus   MeSH
• lysinhydroxylasa metabolismus   MeSH
• multiproteinové komplexy metabolismus   MeSH
• mutace genetika   MeSH
• myši MeSH
• peptidy metabolismus   MeSH
• povrchová plasmonová rezonance MeSH
• prokolagen metabolismus   MeSH
• proteiny tepelného šoku HSP47 metabolismus   MeSH
• proteiny teplotního šoku metabolismus   MeSH
• proteiny vázající takrolimus metabolismus   MeSH
• stabilita enzymů MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• chaperon endoplazmatického retikula BiP MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• FKBP10 protein, human MeSH Prohlížeč
• kolagen typu I MeSH
• lysin MeSH
• lysinhydroxylasa MeSH
• multiproteinové komplexy MeSH
• peptidy MeSH
• prokolagen MeSH
• proteiny tepelného šoku HSP47 MeSH
• proteiny teplotního šoku MeSH
• proteiny vázající takrolimus MeSH
• SERPINH1 protein, human MeSH Prohlížeč

Malignant melanoma is a malignancy located predominantly in the skin and the incidence of melanoma increases. We compared the markers of bone metabolism - osteocalcin (OC), beta-carboxyterminal cross-linked telopeptide of type I collagen (β-CrossLaps, β-CTx) and tumour marker - human epididymis protein 4 (HE4) in the serum with finding during the entry examination and the check-up of whole-body bone scintigraphy of the patient with a malignant melanoma. Serum concentrations of OC, β-CTx, HE4 were determined in 1 patient (female, age 64 years) with malignant melanoma and correlated with the presence of equivocal bone metastases detected by whole-body bone scintigraphy (the entry examination and check-up after 6 months). Concentrations of bone metabolism markers decreased during six months and we observed progress in bone metastases. The change of the markers levels during the entry examination and the check-up of the whole-body bone scintigraphy with equivocal finding of bone metastases could be a sign of a possible initiating progression of malignant melanoma despite a clinically negative finding that does not prove the progression of the disease.

• Klíčová slova
• Beta-carboxyterminal cross-linked telopeptide of type I collagen, Bone scintigraphy, Human epididymis protein 4, Malignant melanoma, Osteocalcin,
• MeSH
• kolagen typu I krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• melanom krev   patologie   MeSH
• nádorové biomarkery krev   MeSH
• nádory kostí krev   diagnostické zobrazování   sekundární   MeSH
• nádory kůže krev   patologie   MeSH
• osteokalcin krev   MeSH
• peptidy krev   MeSH
• radioisotopová scintigrafie MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kolagen typu I MeSH
• nádorové biomarkery MeSH
• osteokalcin MeSH
• peptidy MeSH

To elucidate the role of endogenous calcitonin (CT) in the regulation of bone resorption, we evaluated the acute effects of an intravenous calcium load in nine patients after total thyroidectomy (aged 29.2 +/- 8 years) compared with nine healthy subjects. After overnight fasting, intravenous infusions of elemental calcium 1.7 mg/kg body weight were given over a 10-minute period. Blood samples for measurements of serum ionized calcium (S-iCa), plasma intact CT, parathyroid hormone (PTH), and plasma type I collagen cross-linked C-terminal telopeptide (beta-CTX) were obtained 3 minutes before and at 13, 30, 60, 90, and 150 minutes after the start of the infusion. At baseline, parameters of calcium and bone metabolism were similar in both groups. A similar increase in S-iCa and decrease in plasma PTH levels were observed in both groups. However, the plasma CT increased significantly by 13 minutes (P < 0.05) and beta-CTX decreased significantly as early as 30 minutes (P < 0.05) (decrease by 36% as compared with the baseline) only in the group consisting of healthy individuals. In the thyroidectomized group, the plasma beta-CTX did not decrease significantly during the first 60 minutes (decrease by only 8% as compared with the baseline) and response to the calcium load was significantly diminished throughout the study period as compared with that of the healthy subjects (P < 0.01). In conclusion, the results indicate that the increased CT secretion is responsible for the rapid initial decrease in the bone resorption following an acute intravenous calcium load.

• MeSH
• dospělí MeSH
• intravenózní infuze MeSH
• kalcitonin krev   metabolismus   MeSH
• kolagen typu I MeSH
• kolagen krev   MeSH
• lidé MeSH
• mladiství MeSH
• osteoklasty účinky léků   metabolismus   MeSH
• parathormon krev   MeSH
• peptidy krev   MeSH
• resorpce kosti farmakoterapie   metabolismus   MeSH
• tyreoidektomie * MeSH
• vápník aplikace a dávkování   krev   farmakologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kalcitonin MeSH
• kolagen typu I MeSH
• kolagen MeSH
• parathormon MeSH
• peptidy MeSH
• vápník MeSH

An increase in procollagen type I amino-terminal propeptide (PINP) early after teriparatide initiation was shown to correlate with increased lumbar spine areal BMD and is a good predictor of the anabolic response to teriparatide. Few data exist correlating PINP and bone microstructure, and no data exist in patients on teriparatide following prior potent antiresorptive treatment. This exploratory analysis aimed to investigate the effects of teriparatide on cancellous bone microstructure and correlations of bone markers with microstructure in alendronate-pretreated patients. This was a post hoc analysis of changes in bone markers and three-dimensional indices of bone microstructure in paired iliac crest biopsies from a prospective teriparatide treatment study in postmenopausal women with osteoporosis who were either treatment-naïve (TN, n=16) or alendronate-pretreated (ALN, n=29) at teriparatide initiation. Teriparatide (20μg/day) was given for 24months; biopsies were taken at baseline and endpoint, and serum concentrations of PINP and type 1 collagen cross-linked C-telopeptide (βCTX) were measured at intervals up to 24months. In the TN and ALN groups, respectively, mean (SD) increases in three-dimensional bone volume/tissue volume were 105 (356)% (P=0.039) and 55 (139)% (P<0.005) and trabecular thickness 30.4 (30)% (P<0.001) and 30.8 (53)% (P<0.001). No significant changes were observed in trabecular number or separation. In the ALN patients, 3-month change of neither PINP nor βCTX correlated with indices of cancellous bone microstructure. However, 12-month changes in biochemical bone markers correlated significantly with improvements in bone volume/tissue volume, r=0.502 (P<0.01) and r=0.378 (P<0.05), trabecular number, r=0.559 (P<0.01) and r=0.515 (P<0.01), and reduction of trabecular separation, r=-0.432 (P<0.05) and r=-0.530 (P<0.01), for PINP and βCTX, respectively. We conclude that cancellous bone microstructure improved with teriparatide therapy irrespective of prior antiresorptive use.

• Klíčová slova
• Alendronate pretreatment, Cancellous bone microstructure, PINP, Teriparatide, Turnover markers,
• MeSH
• alendronát terapeutické užití   MeSH
• inhibitory kostní resorpce terapeutické užití   MeSH
• kolagen typu I krev   MeSH
• kostní denzita účinky léků   MeSH
• lidé středního věku MeSH
• lidé MeSH
• peptidové fragmenty krev   MeSH
• peptidy krev   MeSH
• postmenopauzální osteoporóza farmakoterapie   MeSH
• prokolagen krev   MeSH
• remodelace kosti účinky léků   MeSH
• senioři MeSH
• teriparatid terapeutické užití   MeSH
• trabekulární kostní tkáň účinky léků   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Názvy látek
• alendronát MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• inhibitory kostní resorpce MeSH
• kolagen typu I MeSH
• peptidové fragmenty MeSH
• peptidy MeSH
• procollagen Type I N-terminal peptide MeSH Prohlížeč
• prokolagen MeSH
• teriparatid MeSH

UNLABELLED: The authors examined 79 patients (n = 79) with primary and secondary osteoporosis, incl.31 men (nM = 31) aged 31-61 years and 48 women (nF = 48, aged 33 to 65 years. In these patients they assessed NTx (amino-terminal telopeptide of type I collagen of the Ist organic bone matrix) in 24 (NTx24) and 2-hour morning (NTx2) diuresis (from 6 to 8 a.m.). OBJECTIVE: 1. To assess the relationship between values of NTx in th suggested 2-hour diuresis and NTx values in the standard 24- hour diuresis differentiated by sex. 2. To compare the ratio (index) of widths of 95% confidence intervals (CI) for NTx2 and NTx24 with the ratio (index) of reference widths (manual OSTEX, USA) for NTx in the first morning urine (NTx1) and for NTX24 differentiated by sex. 3. Evaluate the suggested 2-hour diuresis for assessment of NTx. STATISTICAL ANALYSIS: Stochastic-determinist linear regression analysis. RESULTS: 1. Between values NTx24 and NTx2 a statistically significant regression correlation was found (p < 0.001) (men: r = 0.352, women r2 = 0.781). The indices of widths of reference limits (IR) of OSTEX Co. USA reach values 2.1 times higher (0.7 times) than indices of widths of CI for osteoporosis (IO) in men as well as women. CONCLUSION: 1. Between values of NTx24 and NTx2 is a significant regression relation. Both urine samples can be used for assessment of the NTx level. 2. Higher values of IR and IO indices for women as well as men confirm a greater dispersal of NTx1 values as compared with NTx2 values. 3. Introduction of two-hour morning diuresis will reduce the extent of variation of NTx values during repeated examinations and provide more accurate information as compared with assessment of NTx in any of the first morning samples of urine according to instructions of the manufacturers of the kits.

• MeSH
• biologické markery moč   MeSH
• diuréza MeSH
• dospělí MeSH
• kolagen typu I MeSH
• kolagen moč   MeSH
• lidé středního věku MeSH
• lidé MeSH
• odběr biologického vzorku metody   normy   MeSH
• osteoporóza diagnóza   moč   MeSH
• peptidy moč   MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• biologické markery MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kolagen typu I MeSH
• kolagen MeSH
• peptidy MeSH

PURPOSE: The International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) have proposed procollagen type I N propeptide (PINP) and β isomerized C-terminal telopeptide of type I collagen (β-CTX-I) as reference bone turnover markers (BTMs) for osteoporosis. This report examines the published literature since the 2011 IOF-IFCC position paper in order to determine the clinical potential of the reference BTMs and newer markers for the prediction of fracture risk and monitoring the treatment of osteoporosis. METHODS: Evidence for the relationship between BTMs and subsequent fractures was gathered from prospective studies through literature review of the Medline database from years 2011 to May 2024. The impact of treatment on BTMs was also studied by examining publications in that period. Studies of the accuracy of BTMs in the assessment of bone turnover in the setting of advanced chronic kidney disease were also examined. RESULTS: Increased BTM concentrations are associated with higher fracture risk in postmenopausal women. PINP and β-CTX-I measured in blood are associated with fracture risk but their interaction with other risk factors has not been sufficiently studied limiting their incorporation into fracture risk algorithms. Treatment-induced changes in PINP and β-CTX-I account for a substantial proportion of fracture risk reduction and are useful for improving adherence; they are recommended for inclusion in studies to examine adherence in individual patients. However, total PINP (tPINP) and β-CTX-I may be elevated in CKD due to renal retention. Bone alkaline phosphatase (BALP), intact PINP (iPINP), and tartrate resistant acid phosphatase 5b (TRACP5b) show the most promise in discriminating high and low turnover bone diseases in patients with advanced CKD and for predicting fracture risk, monitoring treatment response, and assessing the risk of treatment-related complications. CONCLUSION: We re-affirm the use of serum/plasma tPINP and plasma β-CTX-I as reference BTMs with appropriate patient preparation and sample handling and measurement by standardized/harmonized assays in clinical studies to accumulate further data, and for monitoring treatment of osteoporosis in the setting of normal renal function in clinical practice. BALP and TRACP5b, measured by standardized assays, are recommended as reference BTMs for CKD-associated osteoporosis and should be included in observational and intervention studies to ascertain their utility for risk-evaluation, treatment initiation, and assessment of treatment response in CKD-associated osteoporosis.

• Klíčová slova
• BALP, Bone status indices, Bone turnover markers, PINP, TRACP5b, β-CTX-I,
• MeSH
• biologické markery krev   MeSH
• hodnocení rizik metody   MeSH
• inhibitory kostní resorpce terapeutické užití   MeSH
• kolagen typu I krev   MeSH
• konsensus MeSH
• lidé MeSH
• osteoporotické fraktury prevence a kontrola   etiologie   MeSH
• osteoporóza * diagnóza   patofyziologie   farmakoterapie   krev   terapie   MeSH
• peptidové fragmenty krev   MeSH
• peptidy krev   MeSH
• prokolagen krev   MeSH
• remodelace kosti * fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• konsensus - konference MeSH
• přehledy MeSH
• Názvy látek
• biologické markery MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• inhibitory kostní resorpce MeSH
• kolagen typu I MeSH
• peptidové fragmenty MeSH
• peptidy MeSH
• procollagen Type I N-terminal peptide MeSH Prohlížeč
• prokolagen MeSH

Ageing is associated with the accumulation of damage to all the macromolecules within and outside cells leading to progressively more cellular and tissue defects and resulting in age-related frailty, disability and disease. As a result of the aging process the bone deteriorates in composition, structure and function. Age-related musculoskeletal losses are a major public health burden because they can cause physical disability and increased mortality. We tried to find out on a small set of old women, without risk factors for osteoporosis, what caused them the loss of bone minerals. All 492 women had just only one risk factor - the old age. Laboratory findings have shown a decreased serum C telopeptide and low serum alkaline phosphatase circulating markers, used to quantify bone resorption and formation, and very low level of vitamin D. Very low level of vitamin D that disrupted calcium absorption through the intestine, and decreased calcemia increased parathyroid hormone levels with resulting bone effect. The manifestation of physiological aging is worsening eyesight, peripheral neuropathy, depression, worsening of physical condition, skin aging, sarcopenia and bone mineral loss. Senile osteoporosis, which is not caused by known risk factors for osteoporosis, does not appear to be a separate disease, but is part of the physiological process of aging. Treatment of senile osteoporosis should be focused on the control of secondary hyperparathyroidism by administration of vitamin D and calcium. The risk of fractures in the advanced age is determined by a large number of factors ranging from hazards in the home environment to frailty and poor balance.

• Klíčová slova
• Aging, Frailty, Osteoporosis, Sarcopenia,
• MeSH
• alkalická fosfatasa krev   MeSH
• kolagen typu I krev   MeSH
• kostní denzita MeSH
• lidé MeSH
• osteogeneze MeSH
• osteoporóza krev   MeSH
• parathormon krev   MeSH
• peptidy krev   MeSH
• stárnutí krev   patologie   MeSH
• vápník metabolismus   MeSH
• vitamin D krev   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• alkalická fosfatasa MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• kolagen typu I MeSH
• parathormon MeSH
• peptidy MeSH
• vápník MeSH
• vitamin D MeSH

UNLABELLED: A 12-month morning teriparatide (TPTD) administration resulted in a larger increase in the lumbar spine bone mineral density (BMD) than the evening application. The results indicate that the response of bone cells to teriparatide treatment depends on dosing time. INTRODUCTION: The aim of this study was to assess the long-term effects of the morning vs. the evening teriparatide administration on BMD and bone turnover markers (BTMs) in postmenopausal osteoporosis. METHODS: Fifty women with established postmenopausal osteoporosis were randomized to 12-month treatment with 20 μg of TPTD, administered daily in the morning or in the evening. The BMD and serum concentrations of C-terminal telopeptide of type I collagen, N-terminal propeptide of type I procollagen (PINP), and tartrate-resistant acid phosphatase isoform 5b (TRAP 5b) were measured at baseline, after 6 and 12 months. General linear model-repeated measurements were used to analyze the data. RESULTS: After 12 months, the lumbar spine BMD grew markedly (p < 0.001) with a significantly greater increase in the morning arm compared to the evening arm (9.1% vs. 4.8%, respectively, p < 0.05). The BMD at the distal radius significantly decreased (p < 0.001), with no differences between the arms. The BMD at proximal femur did not change significantly. After 6 months, the BTMs were significantly increased compared with baseline (p < 0.001). The increases in the evening arm vs. the morning arm, however, were more pronounced in PINP (+358% vs. +215%, respectively) and in TRAP 5b (+70% vs. +37%, respectively) (both p < 0.05). CONCLUSION: 12-month morning administration of TPTD resulted in a larger increase in the lumbar spine BMD than the evening application. The timing of TPTD administration may be important for its efficacy.

• MeSH
• bederní obratle patofyziologie   MeSH
• biologické markery krev   MeSH
• fosfáty krev   MeSH
• inhibitory kostní resorpce aplikace a dávkování   terapeutické užití   MeSH
• injekce subkutánní MeSH
• izoenzymy krev   MeSH
• kolagen typu I krev   MeSH
• kostní denzita účinky léků   MeSH
• kyselá fosfatasa rezistentní k tartarátu MeSH
• kyselá fosfatasa krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• peptidové fragmenty krev   MeSH
• peptidy krev   MeSH
• postmenopauzální osteoporóza krev   farmakoterapie   patofyziologie   MeSH
• prokolagen krev   MeSH
• rozvrh dávkování léků MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• teriparatid aplikace a dávkování   terapeutické užití   MeSH
• vápník krev   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• biologické markery MeSH
• collagen type I trimeric cross-linked peptide MeSH Prohlížeč
• fosfáty MeSH
• inhibitory kostní resorpce MeSH
• izoenzymy MeSH
• kolagen typu I MeSH
• kyselá fosfatasa rezistentní k tartarátu MeSH
• kyselá fosfatasa MeSH
• peptidové fragmenty MeSH
• peptidy MeSH
• procollagen Type I N-terminal peptide MeSH Prohlížeč
• prokolagen MeSH
• teriparatid MeSH
• vápník MeSH