Neuroblastomas are tumors of the sympathetic nervous system. Unfortunately, this group of tumors has not shown the same remarkable progress in cure rate that has been achieved in most other childhood malignancies and this is one of the reasons why neuroblastomas have been studied so extensively by pediatric oncologists worldwide. The current treatment of neuroblastoma may involve chemotherapy, surgery, radiation therapy, bone marrow rescue and/or innovative biological approaches. Localized tumors, especially those with favorable biology, are curable by surgery alone, as residual tumor tissue is prone to spontaneous regression or differentiation. An intermediate group may be curable with chemotherapy of moderate intensity. However, patients over a year of age with metastatic disease, as well as those with biologically unfavorable regional tumors, seem to have a benefit of a treatment with intensive multiagent chemotherapy with bone marrow

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Index: s. 571-582