This unique book integrates the expertise of over 50 authorities from the laboratories of industry, academia, the military, the government, and blood banks to present a cohesive and up-to-date summary of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of safe and effective red blood cell substitutes. Red Blood Cell Substitutes examines regulatory and socioeconomic aspects of blood substitute products and global transfusion practices from the perspective of blood banks and the U.S. Food and Drug Administration elucidates the mechanisms of action and consequences of blood substitute administration elaborates on the interactions of red cell substitutes with organ systems as well as impact on human physiology details laboratory and clinical efforts to develop chemically modified, encapsulated, recombinant, and transgenic hemoglobin, in addition to fluorocarbon solutions reviews recent data from ongoing preclinical and clinical trials, including safety issues regarding red blood substitute products addresses second generation blood substitutes as well as future directions, such as the prospects of modified hemoglobin, cross-linked hemoglobin, and encapsulated hemoglobin and more! Complete with references, tables, equations, drawings, and photographs, Blood Cell Substitutes is a valuable resource for general, trauma, and cardiovascular surgeons; biomedical and materials engineers; hematologists; oncologists; liposome researchers; blood bank personnel; health care managers; and graduate and medical school students in these disciplines.

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