Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases. Disregulation of this balance can lead to cellular transformation. Here we review knowledge of the mechanisms of one protein phosphatase, the tumour suppressor PTEN/MMAC/TEP 1 apropos its role in tumorigenesis and signal transduction. PTEN plays an important role in the phosphatidyl-inositol-3-kinase (PI3-K) pathway by catalyzing degradation of phosphatidylinositol-(3,4,5)-triphosphate generated by PI3-K. This inhibits downstream targets mainly protein kinase B (PKB/Akt), cell survival and proliferation. PTEN contributes to cell cycle regulation by blockade of cells entering the S phase of the cell cycle, and by upregulation of p27(Kip1) which is recruited into the cyclin E/cdk2 complex. PTEN also modulates cell migration and motility by regulation of the extracellular signal-related kinase - mitogen activated protein kinase (ERK-MAPK) pathway and by dephosphorylation of focal adhesion kinase (FAK). We also emphasize the increasingly important role that PTEN has from an evolutionary point of view. A number of PTEN functions have been elucidated but more information is needed for utilization in clinical application and potential cancer therapy.

Institute of Pathology and Laboratory of Molecular Pathology Faculty of Medicine Palacký University Olomouc

Lit: 45

000      

00000naa a2200000 a 4500

001      

bmc04007535

003      

CZ-PrNML

005      

20141120143709.0

008      

040600s2003 xr u eng||

009      

AR

040    __

$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xr

100    1_

$a Hlobilková, Alice, $d 1972- $4 aut $7 xx0019008

245    14

$a The mechanism of action of the tumour suppressor gene PTEN / $c Alice Hlobilková, Jana Knillová, Jiří Bártek

314    __

$a Institute of Pathology and Laboratory of Molecular Pathology, Faculty of Medicine, Palacký University, Olomouc, CZ

504    __

$a Lit: 45

520    9_

$a Intracellular levels of phosphorylation are regulated by the coordinated action of protein kinases and phosphatases. Disregulation of this balance can lead to cellular transformation. Here we review knowledge of the mechanisms of one protein phosphatase, the tumour suppressor PTEN/MMAC/TEP 1 apropos its role in tumorigenesis and signal transduction. PTEN plays an important role in the phosphatidyl-inositol-3-kinase (PI3-K) pathway by catalyzing degradation of phosphatidylinositol-(3,4,5)-triphosphate generated by PI3-K. This inhibits downstream targets mainly protein kinase B (PKB/Akt), cell survival and proliferation. PTEN contributes to cell cycle regulation by blockade of cells entering the S phase of the cell cycle, and by upregulation of p27(Kip1) which is recruited into the cyclin E/cdk2 complex. PTEN also modulates cell migration and motility by regulation of the extracellular signal-related kinase - mitogen activated protein kinase (ERK-MAPK) pathway and by dephosphorylation of focal adhesion kinase (FAK). We also emphasize the increasingly important role that PTEN has from an evolutionary point of view. A number of PTEN functions have been elucidated but more information is needed for utilization in clinical application and potential cancer therapy.

650    _2

$a tumor supresorové geny $7 D016147

650    _2

$a nádory $x RŮST A VÝVOJ $x TERAPIE $7 D009369

650    _2

$a nádorové supresorové proteiny $7 D025521

650    _2

$a regulace genové exprese u nádorů $7 D015972

650    _2

$a buněčný cyklus $x PATOFYZIOLOGIE $7 D002453

650    _2

$a lidé $7 D006801

650    _2

$a finanční podpora výzkumu jako téma $7 D012109

700    1_

$a Knillová, Jana $4 aut

700    1_

$a Kolář, Zdeněk, $d 1953- $4 aut $7 jn20000710256

700    1_

$a Bártek, Jiří, $d 1953- $7 xx0046271

700    1_

$a Lukáš, Jiří $7 xx0094305

773    0_

$w MED00012606 $t Biomedical papers $g Roč. 147, č. 1 (2003), s. 19-25 $x 1213-8118

910    __

$a ABA008 $b A 1502 $y 0 $z 0

990    __

$a 20040713 $b ABA008

991    __

$a 20141120143750 $b ABA008

BAS    __

$a 3

BMC    __

$a 2003 $b Roč. 147 $c č. 1 $d s. 19-25 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $x MED00012606

GRA    __

$a NC6779 $p MZ0