• Je něco špatně v tomto záznamu ?

Reactivation of acetycholinesterase inhibited by the pesticide chlorpyrifos

Veronika Račáková, Daniel Jun, Veronika Opletalová, Kamil Kuča

. 2006 ; 4 (3) : 147-151.

Jazyk čeština Země Česko

Perzistentní odkaz   https://www.medvik.cz/link/bmc07500663

Organophosphorus pesticides such as parathion or chlorpyrifos are substances used worldwide for agricultural purposes. These compounds are able to inhibit an enzyme acetylcholinesterase (AChE; EC 3.1.1.7) by phosphorylation in its active site. AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication by these agents. In this work, the reactivation potency of nine structurally different AChE reactivators was tested in vitro. Chlorpyrifos was chosen as an appropriate member of the pesticide family. The result is that bisquaternary reactivators with two oxime groups in position four at the pyridinium rings (trimedoxime and K074) seem to be the most potent reactivators of chlorpyrifos-inhibited AChE.

Citace poskytuje Crossref.org

Bibliografie atd.

Lit.: 20

000      
02537naa 2200409 a 4500
001      
bmc07500663
003      
CZ-PrNML
005      
20111210120922.0
008      
070813s2006 xr e cze||
009      
AR
024    7_
$a 10.32725/jab.2006.016 $2 doi
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a cze
044    __
$a xr
100    1_
$a Račáková, Veronika. $7 _BN000956
245    10
$a Reactivation of acetycholinesterase inhibited by the pesticide chlorpyrifos / $c Veronika Račáková, Daniel Jun, Veronika Opletalová, Kamil Kuča
314    __
$a Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy, Charles University, Hradec Králové
504    __
$a Lit.: 20
520    9_
$a Organophosphorus pesticides such as parathion or chlorpyrifos are substances used worldwide for agricultural purposes. These compounds are able to inhibit an enzyme acetylcholinesterase (AChE; EC 3.1.1.7) by phosphorylation in its active site. AChE reactivators and anticholinergics are generally used as antidotes in the case of intoxication by these agents. In this work, the reactivation potency of nine structurally different AChE reactivators was tested in vitro. Chlorpyrifos was chosen as an appropriate member of the pesticide family. The result is that bisquaternary reactivators with two oxime groups in position four at the pyridinium rings (trimedoxime and K074) seem to be the most potent reactivators of chlorpyrifos-inhibited AChE.
650    _2
$a acetylcholinesterasa $x farmakologie $x metabolismus $7 D000110
650    _2
$a pesticidy $x farmakologie $x metabolismus $x škodlivé účinky $7 D010575
650    _2
$a dursban $x farmakologie $x metabolismus $x škodlivé účinky $7 D004390
650    _2
$a reaktivní inhibice $7 D011931
650    _2
$a interpretace statistických dat $7 D003627
650    _2
$a lidé $7 D006801
650    _2
$a techniky in vitro $7 D066298
700    1_
$a Jun, Daniel, $d 1976- $7 xx0040498
700    1_
$a Opletalová, Veronika, $d 1955- $7 jn20000620259
700    1_
$a Kuča, Kamil, $d 1978- $7 xx0041831
773    0_
$w MED00012667 $t Journal of applied biomedicine $g Roč. 4, č. 3 (2006), s. 147-151 $x 1214-021X
856    41
$u https://jab.zsf.jcu.cz/pdfs/jab/2006/03/06.pdf $y plný text volně přístupný
910    __
$y 1 $a ABA008 $b B 2301 $c 1249
990    __
$a 20070813090340 $b ABA008
991    __
$a 20110509102801 $b ABA008
999    __
$a ok $b bmc $g 616275 $s 468707
BAS    __
$a 3
BMC    __
$a 2006 $b 4 $c 3 $d 147-151 $i 1214-021X $m Journal of Applied Biomedicine $x MED00012667
LZP    __
$a 2007-7/mkjb

Najít záznam

Citační ukazatele

Možnosti archivace