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Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells
Jiří Pacherník, V. Horváth, L. Kubala, P. Dvořák, A. Kozubík, A. Hampl
Jazyk angličtina Země Česko
NLK
Free Medical Journals
od 2000
Freely Accessible Science Journals
od 2000
ProQuest Central
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2000
- MeSH
- buněčná diferenciace MeSH
- embryonální karcinom genetika MeSH
- embryonální kmenové buňky MeSH
- finanční podpora výzkumu jako téma MeSH
- interleukin-6 farmakokinetika farmakologie MeSH
- myši MeSH
- nádorové buňky kultivované MeSH
- pluripotentní kmenové buňky MeSH
- techniky in vitro MeSH
- transkripční faktor STAT3 farmakokinetika MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
LIF is a cytokine playing a key role in the regulation of self-renewal and maintenance of undifferentiated state in mouse ES cells. The response of pluripotent cells to LIF is mediated mainly by the STAT3 and ERK signalling pathways. Recently, we have shown that LIF potentiated retinoic acid-induced neural differentiation of pluripotent mouse embryonal carcinoma P19 cells. Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway.
Grant č. 524/03/P171 GAČR
Grant č. AVOZ50390512 GAAV ČR
Grant č. 1M0021620803 MŠMT ČR
Bibliografie atd.Lit.: 25
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- $a LIF is a cytokine playing a key role in the regulation of self-renewal and maintenance of undifferentiated state in mouse ES cells. The response of pluripotent cells to LIF is mediated mainly by the STAT3 and ERK signalling pathways. Recently, we have shown that LIF potentiated retinoic acid-induced neural differentiation of pluripotent mouse embryonal carcinoma P19 cells. Here we demonstrate that pro-neural effects of LIF and partially also of retinoic acid are abolished by inhibition of the JAK2->STAT3 signalling pathway. In contrast, inhibition of the MEK1->ERK signalling pathway does not exhibit any effect. These results suggest that in neurogenic regions, cooperative action of LIF and other neuro-differentiation-inducing factors, such as retinoic acid, may be mediated by the STAT3 signalling pathway.
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