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Highly lipophilic p-carborane-modified adenosine phosphates
Blazej A. Wojtczak, Agnieszka B. Olejniczak, Marzena Przepiorkiewicz, Agnieszka Andrysiak , Zbigniew J. Lesnikowski
Jazyk angličtina Země Česko
- MeSH
- adeninnukleotidy chemická syntéza MeSH
- AMP cyklický chemická syntéza MeSH
- financování organizované MeSH
- prekurzory léčiv MeSH
- sloučeniny boru MeSH
- vazba proteinů MeSH
- vazebná místa MeSH
The method was developed for the synthesis of biologically important adenosine phosphates, AMP, cAMP and ATP modified with p-carborane cluster - a highly lipophilic pharmacophore. The adenosine phosphates modified with p-carborane are characterized by increased stability in human blood plasma and much more higher lipophilicity than that of the unmodified phosphates. ATP analog 4 bearing p-carborane cluster is not a Taq polymerase substrate and most probably not the polymerase inhibitor. These properties may have clinical implications.
Citace poskytuje Crossref.org
Presented at the XIII Symposium on Chemistry of Nucleic Acid Components, Špindlerův Mlýn, September 3-9, 2005
Bibliografie atd.Lit.: 24
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