-
Je něco špatně v tomto záznamu ?
Synthesis of some impurities and/or degradation products of atorvastatin
Jan Stach, Jaroslav Havlíček, Lukáš Plaček, Stanislav Rádl
Collection of Czechoslovak Chemical Communications.
2008 ;
73 (2) :
229-246.
Jazyk angličtina Země Česko
Perzistentní odkaz
https://www.medvik.cz/link/bmc07505894
Online
NLK
ProQuest Central
od 2005-01-01 do 2011
- Klíčová slova
- Lipitor, Sortis,
- MeSH
- financování organizované MeSH
- kyseliny heptylové chemická syntéza MeSH
- pyrroly chemická syntéza MeSH
- racionální návrh léčiv MeSH
- statiny chemická syntéza MeSH
Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7- [2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)- and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
Bibliografie atd.
Lit.: 12
- 000
- 02100naa 2200409 a 4500
- 001
- bmc07505894
- 003
- CZ-PrNML
- 005
- 20130331191452.0
- 008
- 080630s2008 xr e eng||
- 009
- AR
- 024 7_
- $2 doi $a 10.1135/cccc20080229
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Stach, Jan, $d 1972- $7 xx0141349
- 245 10
- $a Synthesis of some impurities and/or degradation products of atorvastatin / $c Jan Stach, Jaroslav Havlíček, Lukáš Plaček, Stanislav Rádl
- 314 __
- $a Zentiva, Praha 10
- 504 __
- $a Lit.: 12
- 520 9_
- $a Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7- [2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)- and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
- 650 _2
- $a pyrroly $x chemická syntéza $7 D011758
- 650 _2
- $a kyseliny heptylové $x chemická syntéza $7 D006538
- 650 _2
- $a statiny $x chemická syntéza $7 D019161
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a racionální návrh léčiv $7 D015195
- 653 00
- $a Lipitor
- 653 00
- $a Sortis
- 700 1_
- $a Havlíček, Jaroslav, $d 1961- $7 jo2003190657
- 700 1_
- $a Plaček, Lukáš. $7 _BN004562
- 700 1_
- $a Rádl, Stanislav, $7 jx20061013029 $d 1951-
- 773 0_
- $w MED00010973 $t Collection of Czechoslovak chemical communications $g Roč. 73, č. 2 (2008), s. 229-246 $x 0010-0765
- 910 __
- $a ABA008 $b A 1006 $c 394 $y 9
- 990 __
- $a 20080625111328 $b ABA008
- 991 __
- $a 20130331191735 $b ABA008
- 999 __
- $a ok $b bmc $g 621516 $s 473949
- BAS __
- $a 3
- BMC __
- $a 2008 $b 73 $c 2 $d 229-246 $i 0010-0765 $m Collection of Czechoslovak Chemical Communications $x MED00010973
- LZP __
- $a 2008-16/vtmv
