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Synthesis of some impurities and/or degradation products of atorvastatin
Jan Stach, Jaroslav Havlíček, Lukáš Plaček, Stanislav Rádl
Collection of Czechoslovak Chemical Communications.
2008 ;
73 (2) :
229-246.
Language English Country Czech Republic
Persistent link
https://www.medvik.cz/link/bmc07505894
- Keywords
- Lipitor, Sortis,
- MeSH
- Financing, Organized MeSH
- Heptanoic Acids chemical synthesis MeSH
- Pyrroles chemical synthesis MeSH
- Drug Design MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors chemical synthesis MeSH
Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7- [2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)- and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
References provided by Crossref.org
Bibliography, etc.
Lit.: 12
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