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Synthesis of some impurities and/or degradation products of atorvastatin
Jan Stach, Jaroslav Havlíček, Lukáš Plaček, Stanislav Rádl
Collection of Czechoslovak Chemical Communications.
2008 ;
73 (2) :
229-246.
Language English Country Czech Republic
Persistent link
https://www.medvik.cz/link/bmc07505894
Online
NLK
ProQuest Central
from 2005-01-01 to 2011
- Keywords
- Lipitor, Sortis,
- MeSH
- Financing, Organized MeSH
- Heptanoic Acids chemical synthesis MeSH
- Pyrroles chemical synthesis MeSH
- Drug Design MeSH
- Hydroxymethylglutaryl-CoA Reductase Inhibitors chemical synthesis MeSH
Synthesis of some impurities and/or degradation products of atorvastatin, calcium (3R,5R)-7- [2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate, is described. These include its desfluoro analog, the corresponding (3S,5S)- and (3S,5R)-epimers, atorvastatin lactone, and some other potential impurities. The synthesized compounds as well as the corresponding intermediates were characterized by 1H NMR, 13C NMR and MS.
Bibliography, etc.
Lit.: 12
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