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Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine
Zajoncova L, Kosina P, Vicar J, Ulrichová J, Pec P.
Jazyk angličtina Země Velká Británie
NLK
Taylor & Francis Open Access
od 2002-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2002
- MeSH
- alfa-amylasy antagonisté a inhibitory metabolismus MeSH
- alkaloidy farmakologie metabolismus MeSH
- biosenzitivní techniky MeSH
- časové faktory MeSH
- fenantridiny farmakologie metabolismus MeSH
- financování organizované MeSH
- inhibitory enzymů farmakologie MeSH
- kinetika MeSH
- lidé MeSH
- prasata MeSH
- stabilita enzymů MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2.1.1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 microM sanguinarine and 250 microM chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid.
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- $a Zajoncová, Ludmila, $d 1957- $7 jo20000082921
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- $a Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine / $c Zajoncova L, Kosina P, Vicar J, Ulrichová J, Pec P.
- 314 __
- $a Department of Biochemistry, Faculty of Science, Palacký University, Slechtitelů 11, 783 71, Olomouc, Czech Republic. zajoncov@prfholnt.upol.cz
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- $a Inhibition of porcine pancreas and human saliva alpha-amylase (EC 3.2.1.1) by sanguinarine and chelerythrine was studied. The inhibition of alpha-amylase was assayed using a biosensor method which utilises a flow system equipped with a peroxide electrode. 250 microM sanguinarine and 250 microM chelerythrine cause complete inhibition of 1.9 nkat alpha-amylase from porcine pancreas. The same concentration of sanguinarine and chelerythrine caused 23.9% and 7.5% inhibition, respectively, of 1.9 nkat alpha-amylase from human saliva. Mixed type and partially reversible inhibition was found for both alpha-amylases treated with either alkaloid.
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- $a financování organizované $7 D005381
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