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Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi
Sak B, Salát J, Horká H, Saková K, Ditrich O.
Language English Country Great Britain
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from 1997 to 1 year ago
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from 1997-01-01 to 2012-12-31
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from 1997 to 1 year ago
- MeSH
- Survival Analysis MeSH
- CD4-Positive T-Lymphocytes immunology MeSH
- Encephalitozoon cuniculi immunology MeSH
- Encephalitozoonosis immunology therapy MeSH
- Financing, Organized MeSH
- Immunotherapy methods MeSH
- Antibodies, Monoclonal pharmacology immunology MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Statistics, Nonparametric MeSH
- Spores, Fungal immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.
References provided by Crossref.org
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- $a Institute of Parasitology, Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Ceské Budejovice, Czech Republic. casio@paru.cas.cz
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- $a The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.
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- $a monoklonální protilátky $x farmakologie $x imunologie $7 D000911
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