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Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi
Sak B, Salát J, Horká H, Saková K, Ditrich O.
Jazyk angličtina Země Velká Británie
NLK
Free Medical Journals
od 1997 do Před 1 rokem
Medline Complete (EBSCOhost)
od 1998-01-01 do Před 1 rokem
Wiley Online Library (archiv)
od 1997-01-01 do 2012-12-31
Wiley Free Content
od 1997 do Před 1 rokem
- MeSH
- analýza přežití MeSH
- CD4-pozitivní T-lymfocyty imunologie MeSH
- Encephalitozoon cuniculi imunologie MeSH
- encephalitozoonóza imunologie terapie MeSH
- financování organizované MeSH
- imunoterapie metody MeSH
- monoklonální protilátky farmakologie imunologie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- neparametrická statistika MeSH
- spory hub imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.
Citace poskytuje Crossref.org
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