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Interaction of DNA/polycation complexes with phospholipids: stabilizing strategy for gene delivery
Zintchenko A, Konák C.
Language English Country Germany
NLK
Wiley Online Library (archiv)
from 2001-01-01 to 2012-12-31
- MeSH
- Sodium Chloride chemistry MeSH
- DNA administration & dosage chemistry MeSH
- Financing, Organized MeSH
- Phospholipids chemistry MeSH
- Lipid Bilayers MeSH
- Nanostructures MeSH
- Polylysine chemistry MeSH
- Solutions MeSH
- Gene Transfer Techniques MeSH
The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes.Interaction of DNA/polycation complex particles with lipid vesicles.
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- $a Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovskeho nam. 2, 162 06 Praha 6, Czech Republic. arkadi.zintchenko@cup.uni-muenchen.de
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- $a The interaction between negatively charged lipid vesicles and positively charged DNA/polylysine complexes was studied. The interaction does not lead to release of DNA from the initial complexes. The particles formed are easy to prepare, they have slight negative charge, small dimensions and show good stability in physiological NaCl solution. Such properties might indicate that stabilization of the particles by lipid coating might be a potent strategy, alternative to PEGylation of DNA/polycation complexes.Interaction of DNA/polycation complex particles with lipid vesicles.
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- $a technika přenosu genů $7 D018014
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- $a fosfolipidy $x chemie $7 D010743
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- $a polylysin $x chemie $7 D011107
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- $a chlorid sodný $x chemie $7 D012965
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- $a roztoky $7 D012996
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- $a financování organizované $7 D005381
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- $a Koňák, Čestmír. $7 _AN026017
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- $w MED00006593 $t Macromolecular bioscience $g Roč. 5, č. 12 (2005), s. 1169-1174 $x 1616-5187
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