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Functional polymorphism in the manganese superoxide dismutase (MnSOD) gene in patients with asthma
Holla LI, Kankova K, Vasku A.
Clinical biochemistry.
2006 ;
39 (3) :
299-302.
Jazyk angličtina Země Spojené státy americké
Perzistentní odkaz
https://www.medvik.cz/link/bmc07521363
- MeSH
- alely MeSH
- bronchiální astma genetika MeSH
- dospělí MeSH
- financování organizované MeSH
- frekvence genu MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- lidé MeSH
- polymorfismus genetický genetika MeSH
- studie případů a kontrol MeSH
- superoxiddismutasa genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
OBJECTIVES: To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. METHODS: MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme. RESULTS: Significant differences in allele frequencies between groups were not ascertained. CONCLUSIONS: Pursuant to these results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for bronchial asthma in the Czech population.
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- $a Izakovičová Hollá, Lydie, $d 1971- $7 nlk19990074300
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- $a Department of Pathophysiology, Faculty of Medicine, Masaryk University Brno, Komenskeho nam. 2, 662 43 Brno, Czech Republic. holla@med.muni.cz
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- $a OBJECTIVES: To investigate the possible association between functional variant Ala-9Val in the MnSOD gene and asthma in the case-control study comprising 626 Caucasian subjects. METHODS: MnSOD genotypes were determined by PCR with subsequent restriction analysis by the BsaWI enzyme. RESULTS: Significant differences in allele frequencies between groups were not ascertained. CONCLUSIONS: Pursuant to these results, Ala-9Val polymorphism does not seem to be a significant predisposing factor for bronchial asthma in the Czech population.
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