• Something wrong with this record ?

Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia

Prikryl R, Ceskova E, Kasparek T, Kucerova H.

. 2006 ; 40 (2) : 141-146.

Language English Country Great Britain

OBJECTIVES: To examine the relationship between the severity of neurological soft signs at onset and at the 1-year follow-up of patients with schizophrenia, and to investigate temporal stability of neurological soft signs within 1year from the onset of the first episode schizophrenia. METHODS: The study included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a 1-year follow-up. The patients were divided into remitters and non-remitters according to their psychiatric status assessed at the 1-year follow-up, using the Positive and Negative Syndrome Scale (PANSS). RESULTS: A trend for a lower score for the NES item "others" in late remitters versus non-remitters at baseline was found during index hospitalization. At the 1-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within 1year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within 1year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. CONCLUSION: These findings in a population of patients with first episode schizophrenia are in accord with the findings of previous studies which found an association between neurological soft signs, treatment response and outcome. This association may characterize a subgroup of patients with a poor course of illness and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.

000      
00000naa 2200000 a 4500
001      
bmc07522692
003      
CZ-PrNML
005      
20220628123547.0
008      
090506s2006 xxk e eng||
009      
AR
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Přikryl, Radovan, $d 1974-2015 $7 mzk2008448591
245    10
$a Neurological soft signs and their relationship to 1-year outcome in first-episode schizophrenia / $c Prikryl R, Ceskova E, Kasparek T, Kucerova H.
314    __
$a Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital, Jihlavska 20, 625 00 Brno, Czech Republic. radovan.prikryl@post.cz
520    9_
$a OBJECTIVES: To examine the relationship between the severity of neurological soft signs at onset and at the 1-year follow-up of patients with schizophrenia, and to investigate temporal stability of neurological soft signs within 1year from the onset of the first episode schizophrenia. METHODS: The study included 92 first-episode male schizophrenic patients. Neurological soft signs were assessed on the Neurological Evaluation Scale (NES) during index hospitalization and at a 1-year follow-up. The patients were divided into remitters and non-remitters according to their psychiatric status assessed at the 1-year follow-up, using the Positive and Negative Syndrome Scale (PANSS). RESULTS: A trend for a lower score for the NES item "others" in late remitters versus non-remitters at baseline was found during index hospitalization. At the 1-year follow-up, the overall severity of the neurological soft signs was statistically significantly higher in non-remitters than in remitters. Within 1year after index hospitalization, a significant reduction of neurological soft signs, with the exception of sensory integration, occurred in remitters. Within 1year after index hospitalization, the non-remitters reported a significant reduction of the overall NES score. CONCLUSION: These findings in a population of patients with first episode schizophrenia are in accord with the findings of previous studies which found an association between neurological soft signs, treatment response and outcome. This association may characterize a subgroup of patients with a poor course of illness and outcome. Neurological soft signs might be regarded as one of the indicators of treatment outcome in patients suffering from their first episode of schizophrenia.
650    _2
$a financování organizované $7 D005381
650    _2
$a dospělí $7 D000328
650    _2
$a antipsychotika $x terapeutické užití $7 D014150
650    _2
$a následné studie $7 D005500
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a nemoci nervového systému $x diagnóza $7 D009422
650    _2
$a neurologické vyšetření $x účinky léků $7 D009460
650    _2
$a hodnocení výsledků zdravotní péče $7 D017063
650    _2
$a prognóza $7 D011379
650    _2
$a psychiatrické posuzovací škály $7 D011569
650    _2
$a schizofrenie $x diagnóza $7 D012559
650    _2
$a schizofrenie (psychologie) $7 D012565
700    1_
$a Češková, Eva, $d 1946- $7 jn20001005316
700    1_
$a Kašpárek, Tomáš, $d 1975- $7 xx0031812
700    1_
$a Přikrylová Kučerová, Hana, $d 1977- $7 ola2006340127
773    0_
$w MED00002912 $t Journal of psychiatric research $g Roč. 40, č. 2 (2006), s. 141-146 $x 0022-3956
910    __
$a ABA008 $b x $y 9 $z 0
990    __
$a 20090506084234 $b ABA008
991    __
$a 20220628123543 $b ABA008
999    __
$a ok $b bmc $g 650784 $s 503947
BAS    __
$a 3
BMC    __
$a 2006 $b 40 $c 2 $d 141-146 $i 0022-3956 $m Journal of Psychiatric Research $x MED00002912
LZP    __
$a 2009-B2/vtme

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...