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Regulation of phosphatidylglycerolphosphate synthase in aerobic yeast Kluyveromyces lactis
Elena Tichá, Viktória Polakovičová, Margita Obernauerová
Jazyk angličtina Země Česko
- MeSH
- aerobióza MeSH
- cholin metabolismus MeSH
- fungální proteiny genetika chemie metabolismus MeSH
- genetická transkripce MeSH
- inositol metabolismus MeSH
- Kluyveromyces MeSH
- mitochondrie genetika chemie metabolismus MeSH
- regulace genové exprese enzymů MeSH
- regulace genové exprese u hub MeSH
- terciární struktura proteinů MeSH
- transferasy pro jiné substituované fosfátové skupiny MeSH
The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of Kluyveromyces lactis. Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed. PGS1 mRNA levels were not altered as cells progressed from the exponential to the stationary phase of growth in glucose. PGS1 mRNA abundance was nearly identical in cells growing in a medium with glucose or glycerol as the sole C source during the different growth phases. Regulation of PGS1 expression by exogenous myo-inositol and choline was not mediated at the transcriptional level, the PGPS activity dropped to 70 % after myo-inositol addition.
Lit.: 40
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- 20111210134617.0
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- 090512s2008 xr e eng||
- 009
- AR
- 024 7_
- $2 doi $a 10.1007/s12223-008-0050-x
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- $a eng
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- $a xr
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- $a Tichá, Elena $7 xx0110047
- 245 10
- $a Regulation of phosphatidylglycerolphosphate synthase in aerobic yeast Kluyveromyces lactis / $c Elena Tichá, Viktória Polakovičová, Margita Obernauerová
- 314 __
- $a Department of Microbiology and Virology, Faculty of Science, Comenius University in Bratislava, Bratislava
- 504 __
- $a Lit.: 40
- 520 9_
- $a The KlPGS1 gene encoding phosphatidylglycerolphosphate synthase (PGPS) is essential for the viability and multiplication of Kluyveromyces lactis. Regulation of PGPS expression by factors affecting mitochondrial development (C source, growth phase) and general phospholipid biosynthesis was followed. PGS1 mRNA levels were not altered as cells progressed from the exponential to the stationary phase of growth in glucose. PGS1 mRNA abundance was nearly identical in cells growing in a medium with glucose or glycerol as the sole C source during the different growth phases. Regulation of PGS1 expression by exogenous myo-inositol and choline was not mediated at the transcriptional level, the PGPS activity dropped to 70 % after myo-inositol addition.
- 650 _2
- $a aerobióza $7 D000332
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- $a cholin $x metabolismus $7 D002794
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- $a regulace genové exprese enzymů $7 D015971
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- $a regulace genové exprese u hub $7 D015966
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- $a Kluyveromyces $7 D007716
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- $a mitochondrie $x genetika $x chemie $x metabolismus $7 D008928
- 650 _2
- $a terciární struktura proteinů $7 D017434
- 650 _2
- $a genetická transkripce $7 D014158
- 650 _2
- $a transferasy pro jiné substituované fosfátové skupiny $7 D017855
- 700 1_
- $a Polakovičová, Viktória. $7 xx0174997
- 700 1_
- $a Obernauerová, Margita $7 xx0069964
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- $w MED00011005 $t Folia microbiologica $g Roč. 53, č. 4 (2008), s. 319-324 $x 0015-5632
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- $a 2009-18/mkme
