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The oriented development of antituberculotics: salicylanilides
Waisser K, Matyk J, Divisová H, Husáková P, Kunes J, Klimesová V, Kaustová J, Möllmann U, Dahse HM, Miko M.
Archiv der Pharmazie.
2006 ;
339 (11) :
616-620.
Language English Country Germany
Persistent link
https://www.medvik.cz/link/bmc07524060
Online
NLK
Wiley Online Library (archiv)
from 1996-01-01 to 2012-12-31
- MeSH
- Antitubercular Agents pharmacology chemical synthesis chemistry MeSH
- Financing, Organized MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium avium drug effects MeSH
- Mycobacterium kansasii drug effects MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Salicylanilides pharmacology chemical synthesis chemistry MeSH
- Structure-Activity Relationship MeSH
On the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. 4-Chloro-N-(4-propylphenyl)salicylamide and 5-chloro-N-(4-propylphenyl)salicylamide were selected for preclinical studies.
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- $a Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy, Hradec Králové, Czech Republic. waisser@faf.cuni.cz
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- $a On the basis of our previous results 22 salicylanilides were synthesized. The compounds were tested for in vitro antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. 4-Chloro-N-(4-propylphenyl)salicylamide and 5-chloro-N-(4-propylphenyl)salicylamide were selected for preclinical studies.
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