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Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia
Koudelová J, Rauchová H, Vokurková M.
Jazyk angličtina Země Spojené státy americké
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- financování organizované MeSH
- hypoxie enzymologie MeSH
- krysa rodu rattus MeSH
- L-laktátdehydrogenasa krev metabolismus MeSH
- mozková kůra enzymologie MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
In our previous studies we have found both an increase of lipid peroxidation damage (expressed as levels of thiobarbituric acid-reactive substances) in brain and plasma lactate concentration in 21-day-old rats after a 30-min exposure to hypobaric hypoxia. Pretreatment of rats with L-carnitine decreased both parameters. The aim of our present study was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We followed brain and blood serum LDH activity of 14-, 21- and 90-day-old Wistar rats. We found an increase of brain LDH activity with age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any clear age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats probably due to membrane stabilizing role of L-carnitine. In conclusions, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity.
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- $a Koudelová, Jitka, $d 1944- $7 ja20020044863
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- $a Activity of lactate dehydrogenase in serum and cerebral cortex of immature and mature rats after hypobaric hypoxia / $c Koudelová J, Rauchová H, Vokurková M.
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- $a First Faculty of Medicine, Institute of Physiology, Charles University, 128 00 Prague 2, Czech Republic
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- $a In our previous studies we have found both an increase of lipid peroxidation damage (expressed as levels of thiobarbituric acid-reactive substances) in brain and plasma lactate concentration in 21-day-old rats after a 30-min exposure to hypobaric hypoxia. Pretreatment of rats with L-carnitine decreased both parameters. The aim of our present study was to determine if the L-carnitine-dependent decrease of plasma lactate could be due to a modification of lactate dehydrogenase (LDH) activity. We followed brain and blood serum LDH activity of 14-, 21- and 90-day-old Wistar rats. We found an increase of brain LDH activity with age. However, we did not observe any significant differences in LDH activity after exposure to hypobaric hypoxia or L-carnitine pretreatment. In contrast to brain, serum LDH activity did not show any clear age-dependence. The hypoxia exposure increased LDH activity of 21-day-old rats only. Pretreatment of rats with L-carnitine decreased serum LDH activity of 21- and 90-day-old rats probably due to membrane stabilizing role of L-carnitine. In conclusions, acute hypobaric hypoxia and/or L-carnitine pretreatment modified serum but not brain LDH activity.
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