-
Something wrong with this record ?
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia
Sochorová K., Horváth R., Rožková D., Litzman J., Bartůňková J., Šedivá A., Špíšek R
Language English Country United States
NLK
Free Medical Journals
from 1946 to 1 year ago
Freely Accessible Science Journals
from 1946 to 1 year ago
Open Access Digital Library
from 1946-01-01
Open Access Digital Library
from 1946-01-01
ROAD: Directory of Open Access Scholarly Resources
- MeSH
- Agammaglobulinemia metabolism MeSH
- Antigen-Presenting Cells metabolism MeSH
- Cell Differentiation MeSH
- Dendritic Cells cytology metabolism MeSH
- Financing, Organized MeSH
- Interleukin-6 biosynthesis MeSH
- Humans MeSH
- Tumor Necrosis Factor-alpha biosynthesis MeSH
- Toll-Like Receptor 8 agonists genetics metabolism MeSH
- Check Tag
- Humans MeSH
The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc09003206
- 003
- CZ-PrNML
- 005
- 20120516194254.0
- 008
- 091119s2007 xxu e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Sochorová, Klára, $d 1981- $7 xx0092234
- 245 10
- $a Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia / $c Sochorová K., Horváth R., Rožková D., Litzman J., Bartůňková J., Šedivá A., Špíšek R
- 314 __
- $a Institute of Immunology, Charles University, 2nd Medical School, Prague, Czech Republic
- 520 9_
- $a The critical role of Bruton tyrosine kinase (Btk) in B cells has been documented by the block of B-cell development in X-linked agammaglobulinemia (XLA). Less is known about Btk function in myeloid cells. Several pieces of evidence indicate that Btk is a component of Toll-like receptor (TLR) signaling. We analyzed whether Btk deficiency in XLA is associated with an impaired dendritic cell (DC) compartment or defective TLR signaling. We analyzed the expression of TLRs 1 to 9 on myeloid DCs generated from XLA patients and evaluated their response to activation by specific TLR agonists. We show that XLA patients have normal numbers of circulating DCs. Btk-deficient DCs have no defect in response to stimulation of TLRs 1/2, 2/6, 3, 4, and 5 but display a profound impairment of IL-6 and TNF-alpha production in response to stimulation by TLR-8 cognate agonist, ssRNA. These findings may provide an explanation for the susceptibility to enteroviral infections in XLA patients.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a agamaglobulinemie $x metabolismus $7 D000361
- 650 _2
- $a antigen prezentující buňky $x metabolismus $7 D000938
- 650 _2
- $a buněčná diferenciace $7 D002454
- 650 _2
- $a dendritické buňky $x cytologie $x metabolismus $7 D003713
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a interleukin-6 $x biosyntéza $7 D015850
- 650 _2
- $a toll-like receptor 8 $x agonisté $x genetika $x metabolismus $7 D051200
- 650 _2
- $a TNF-alfa $x biosyntéza $7 D014409
- 700 1_
- $a Horváth, Rudolf, $d 1979- $7 xx0118294
- 700 1_
- $a Rožková, Daniela, $d 1979- $7 xx0118296
- 700 1_
- $a Litzman, Jiří, $7 xx0000488 $d 1958-
- 700 1_
- $a Bartůňková, Jiřina, $d 1958- $7 jn20000400093
- 700 1_
- $a Šedivá, Anna, $d 1955- $7 xx0000191
- 700 1_
- $a Špíšek, Radek, $d 1975- $7 nlk20030145288
- 773 0_
- $w MED00000807 $t Blood $g Roč. 109, č. 6 (2007), s. 2553-2556 $x 0006-4971
- 910 __
- $a ABA008 $b B 405 $y 9
- 990 __
- $a 20090824163150 $b ABA008
- 991 __
- $a 20120516194232 $b ABA008
- 999 __
- $a ok $b bmc $g 692374 $s 554286
- BAS __
- $a 3
- BMC __
- $a 2007 $b 109 $c 6 $d 2553-2556 $i 0006-4971 $m Blood $x MED00000807
- LZP __
- $a 2009-B4/vtme
