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Stanovení toxicity binárních směsí pomocí hepatocytů z potkana
[Determination of toxicity of binary mixtures using rat hepatocytes]
Adéla Pokorná, Miloň Tichý, Jana Nerzdová, Jana Tumová, Iveta Hanzlíková
Chemické listy.
2009 ;
103 (7) :
575-580.
Language Czech Country Czech Republic
Persistent link
https://www.medvik.cz/link/bmc09004403
- MeSH
- Chlorides toxicity MeSH
- Diclofenac toxicity MeSH
- Financing, Organized MeSH
- Hepatocytes drug effects MeSH
- Environmental Pollutants adverse effects MeSH
- Drug Interactions MeSH
- Nickel toxicity MeSH
- In Vitro Techniques MeSH
- Toxicity Tests, Acute MeSH
Primary hepatocyte assay was used to determine acute toxicity of nickel(II) chloride ? 3,4-dichloroaniline and nickel(II) chloride ? sodium diclophenac mixtures. Although the components act by different mechanisms, their acute toxicity was almost additive; it decreased to zero in dependence on the molar ratio of the components. Toxicities of pollutants in environment may decrease due to interactions with other components.
Determination of toxicity of binary mixtures using rat hepatocytes
Bibliography, etc.
Lit.: 24
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- $a Determination of toxicity of binary mixtures using rat hepatocytes
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- $a Státní zdravotní ústav, Praha 10
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- $a Lit.: 24
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- $a Primary hepatocyte assay was used to determine acute toxicity of nickel(II) chloride ? 3,4-dichloroaniline and nickel(II) chloride ? sodium diclophenac mixtures. Although the components act by different mechanisms, their acute toxicity was almost additive; it decreased to zero in dependence on the molar ratio of the components. Toxicities of pollutants in environment may decrease due to interactions with other components.
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