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Correlation of the IgG index and oligoclonal bands in the cerebrospinal fluid of patients with multiple sclerosis

Jan Mares, Roman Herzig, Karel Urbanek, Vladimira Sladkova, Jaroslava Sklenarova, Vojtech Bekarek, Petr Schneiderka, Jana Zapletalova, Petr Kanovsky

. 2008 ; 152 (2) : 247-249.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc10009475

Aims: The aim of this study was to assess the correlation between IgG index values and the number of the oligoclonalIgG bands (OCB) in the cerebrospinal fl uid (CSF) of patients with multiple sclerosis (MS).Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged 18–68, mean 36.6 ±10.1 years). The CSF collected by a lumbar puncture was examined evaluating intrathecal synthesis using the IgGindex and determining OCB. The number of alkaline OCB in the CSF was assessed using the method of isoelectricfocusing. Pearson’s correlation analysis, and homogeneity ?2 test, Mann-Whitney test, paired-sample t-test (parametric)and Wilcoxon signed-ranks test (nonparametric) were used to evaluate the statistical signifi cance of the results. Results: No positive correlation between the IgG index and the number of OCB was found. Mann-Whitney testalso failed to demonstrate any signifi cant diff erence of the IgG index values in patients both with the OCB number? 2 and < 2.Conclusion: This study did not confi rm any correlation between the IgG index values and the OCB number in theCSF of MS patients.

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Lit.: 15

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$a Aims: The aim of this study was to assess the correlation between IgG index values and the number of the oligoclonalIgG bands (OCB) in the cerebrospinal fl uid (CSF) of patients with multiple sclerosis (MS).Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged 18–68, mean 36.6 ±10.1 years). The CSF collected by a lumbar puncture was examined evaluating intrathecal synthesis using the IgGindex and determining OCB. The number of alkaline OCB in the CSF was assessed using the method of isoelectricfocusing. Pearson’s correlation analysis, and homogeneity ?2 test, Mann-Whitney test, paired-sample t-test (parametric)and Wilcoxon signed-ranks test (nonparametric) were used to evaluate the statistical signifi cance of the results. Results: No positive correlation between the IgG index and the number of OCB was found. Mann-Whitney testalso failed to demonstrate any signifi cant diff erence of the IgG index values in patients both with the OCB number? 2 and < 2.Conclusion: This study did not confi rm any correlation between the IgG index values and the OCB number in theCSF of MS patients.
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