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DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells
J Poljakova, E Frei, JE Gomez, D Aimova, T Eckschlager, J Hrabeta, M Stiborova
Jazyk angličtina Země Irsko
NLK
ScienceDirect (archiv)
od 1993-01-01 do 2009-12-31
- MeSH
- adukty DNA biosyntéza MeSH
- elipticiny farmakologie MeSH
- financování organizované MeSH
- leukemie patologie MeSH
- lidé MeSH
- nádorové buněčné linie MeSH
- protinádorové látky farmakologie MeSH
- Check Tag
- lidé MeSH
Ellipticine induces formation of two DNA adducts in leukemia HL-60 and CCRF-CEM cells, identical with deoxyguanosine adducts generated by ellipticine metabolites 13-hydroxyellipticine and 12-hydroxyellipticine in vitro and in vivo. The ellipticine cytotoxicity to HL-60 (IC(50)=0.64microM) and CCRF-CEM cells (IC(50)=4.7microM) correlates with levels of DNA adducts. The different expressions of enzymes activating ellipticine in cells explain this finding. While cytochrome P450 1A1 and cyclooxygenase-1 are expressed in both cells, HL-60 cells express also high levels of another activator, myeloperoxidase. The results suggest the adduct formation as a new mode of antitumor action of ellipticine for leukemia.
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- $a DNA adduct formation by the anticancer drug ellipticine in human leukemia HL-60 and CCRF-CEM cells / $c J Poljakova, E Frei, JE Gomez, D Aimova, T Eckschlager, J Hrabeta, M Stiborova
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- $a Ellipticine induces formation of two DNA adducts in leukemia HL-60 and CCRF-CEM cells, identical with deoxyguanosine adducts generated by ellipticine metabolites 13-hydroxyellipticine and 12-hydroxyellipticine in vitro and in vivo. The ellipticine cytotoxicity to HL-60 (IC(50)=0.64microM) and CCRF-CEM cells (IC(50)=4.7microM) correlates with levels of DNA adducts. The different expressions of enzymes activating ellipticine in cells explain this finding. While cytochrome P450 1A1 and cyclooxygenase-1 are expressed in both cells, HL-60 cells express also high levels of another activator, myeloperoxidase. The results suggest the adduct formation as a new mode of antitumor action of ellipticine for leukemia.
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