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Two step synthesis of a non-symmetric acetylcholinesterase reactivator

K Musilek, K Kuca, V Dohnal, D Jun, J Marek, V Koleckar

. 2007 ; 12 (8) : 1755-1761.

Jazyk angličtina Země Švýcarsko

Perzistentní odkaz   https://www.medvik.cz/link/bmc10013173

The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.

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$a Two step synthesis of a non-symmetric acetylcholinesterase reactivator / $c K Musilek, K Kuca, V Dohnal, D Jun, J Marek, V Koleckar
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$a Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
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$a The newly developed and very promising acetylcholinesterase reactivator (E)-1-(2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
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$a reaktivátory cholinesterasy $x chemická syntéza $7 D002801
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$a bromované uhlovodíky $x chemická syntéza $7 D006842
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$a pyridinové sloučeniny $x chemická syntéza $7 D011726
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$a Kuča, Kamil, $d 1978- $7 xx0041831
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$a Jun, Daniel, $d 1976- $7 xx0040498
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$a Marek, Jan $7 xx0161533
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$a Kolečkář, Vít. $7 _BN002376
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