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Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited
Kamil Kuča, Kamil Musílek, Miroslav Pohanka, Vlastimil Dohnal, Jiří Patočka
Language English Country Czech Republic
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- MeSH
- Acetylcholinesterase metabolism MeSH
- Antidotes pharmacology MeSH
- Chemical Warfare Agents poisoning MeSH
- Financing, Organized MeSH
- Rats MeSH
- Brain metabolism MeSH
- Obidoxime Chloride pharmacology MeSH
- Pesticides poisoning MeSH
- Cholinesterase Reactivators pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
BACKGROUND: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. AIM: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited. METHOD: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. RESULTS AND CONCLUSION: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
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Lit.: 38
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- $a BACKGROUND: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. AIM: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited. METHOD: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. RESULTS AND CONCLUSION: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
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