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Je něco špatně v tomto záznamu ?
Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited
Kamil Kuča, Kamil Musílek, Miroslav Pohanka, Vlastimil Dohnal, Jiří Patočka
Jazyk angličtina Země Česko
NLK
Directory of Open Access Journals
od 2001
Free Medical Journals
od 1998
Medline Complete (EBSCOhost)
od 2007-06-01
ROAD: Directory of Open Access Scholarly Resources
od 2001
- MeSH
- acetylcholinesterasa metabolismus MeSH
- antidota farmakologie MeSH
- chemické bojové látky otrava MeSH
- financování organizované MeSH
- krysa rodu rattus MeSH
- mozek metabolismus MeSH
- obidoxim chlorid farmakologie MeSH
- pesticidy otrava MeSH
- reaktivátory cholinesterázy farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
BACKGROUND: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. AIM: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited. METHOD: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. RESULTS AND CONCLUSION: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
Citace poskytuje Crossref.org
Lit.: 38
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- $a BACKGROUND: Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial. AIM: In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited. METHOD: Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime. RESULTS AND CONCLUSION: It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
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