-
Something wrong with this record ?
Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair
A Halamikova, O Vrana, J Kasparkova, V Brabec
Language English Country Germany
Grant support
NR8562
MZ0
CEP Register
Digital library NLK
Full text - Část
Source
- MeSH
- Time Factors MeSH
- Cisplatin pharmacology chemistry MeSH
- DNA-Directed RNA Polymerases antagonists & inhibitors chemistry MeSH
- DNA chemistry drug effects MeSH
- Financing, Organized MeSH
- HeLa Cells MeSH
- Humans MeSH
- DNA Repair MeSH
- Antineoplastic Agents pharmacology chemistry MeSH
- RNA chemical synthesis chemistry drug effects MeSH
- Cattle MeSH
- Temperature MeSH
- Binding Sites MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Cattle MeSH
- Animals MeSH
Using biochemical methods, we have examined the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (>37 degrees C). We show that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. Our in vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc10026749
- 003
- CZ-PrNML
- 005
- 20140225092219.0
- 008
- 101019s2007 gw e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Halámiková, Anna. $7 mub2011652620
- 245 10
- $a Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair / $c A Halamikova, O Vrana, J Kasparkova, V Brabec
- 314 __
- $a Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i.
- 520 9_
- $a Using biochemical methods, we have examined the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (>37 degrees C). We show that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. Our in vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a protinádorové látky $x farmakologie $x chemie $7 D000970
- 650 _2
- $a vazebná místa $7 D001665
- 650 _2
- $a skot $7 D002417
- 650 _2
- $a cisplatina $x farmakologie $x chemie $7 D002945
- 650 _2
- $a DNA $x chemie $x účinky léků $7 D004247
- 650 _2
- $a oprava DNA $7 D004260
- 650 _2
- $a DNA řízené RNA-polymerasy $x antagonisté a inhibitory $x chemie $7 D012321
- 650 _2
- $a HeLa buňky $7 D006367
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a RNA $x chemická syntéza $x chemie $x účinky léků $7 D012313
- 650 _2
- $a teplota $7 D013696
- 650 _2
- $a časové faktory $7 D013997
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Vrána, Oldřich, $d 1956- $7 xx0097595
- 700 1_
- $a Kašpárková, Jana, $d 1969- $7 xx0068609
- 700 1_
- $a Brabec, Viktor, $d 1944- $7 jo20010087133
- 773 0_
- $w MED00006594 $t ChemBioChem $g Roč. 8, č. 16 (2007), s. 2008-2015 $x 1439-4227
- 910 __
- $a ABA008 $b x $y 7 $z 0
- 990 __
- $a 20101031052310 $b ABA008
- 991 __
- $a 20140225093030 $b ABA008
- 999 __
- $a ok $b bmc $g 801854 $s 666612
- BAS __
- $a 3
- BMC __
- $a 2007 $b 8 $c 16 $d 2008-2015 $i 1439-4227 $m Chembiochem $n Chembiochem $x MED00006594
- GRA __
- $a NR8562 $p MZ0
- LZP __
- $a 2010-B3/vtme
