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Biochemical studies of the thermal effects on DNA modifications by the antitumor cisplatin and their repair
A Halamikova, O Vrana, J Kasparkova, V Brabec
Jazyk angličtina Země Německo
Grantová podpora
NR8562
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
- MeSH
- antitumorózní látky farmakologie chemie MeSH
- časové faktory MeSH
- cisplatina farmakologie chemie MeSH
- DNA řízené RNA-polymerasy antagonisté a inhibitory chemie MeSH
- DNA chemie účinky léků MeSH
- financování organizované MeSH
- HeLa buňky MeSH
- lidé MeSH
- oprava DNA MeSH
- RNA chemická syntéza chemie účinky léků MeSH
- skot MeSH
- teplota MeSH
- vazebná místa MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- skot MeSH
- zvířata MeSH
Using biochemical methods, we have examined the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (>37 degrees C). We show that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. Our in vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia.
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- $a Using biochemical methods, we have examined the effect of two factors that might play a role in the mechanism of the biological activity of cisplatin at elevated temperatures (>37 degrees C). We show that increased temperatures result in distinct alterations in the modification of the target DNA by cisplatin, and in the repair of these modifications. Our in vitro results support the view that the enhanced DNA-cross-linking efficiency of cisplatin and the lower efficiency of native DNA repair mechanisms at higher temperature play at least a partial role in the potentiation of the antitumor effects of cisplatin under conditions of mild hyperthermia.
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