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Automatic formation of hypotheses on the relationships between structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens HK44
Trögl J, Hálová J, Kuncová G, Pařík P.
Folia microbiologica.
2010 ;
55 (5) :
411-417.
Jazyk angličtina Země Česko
Perzistentní odkaz
https://www.medvik.cz/link/bmc10032376
- MeSH
- biosenzitivní techniky MeSH
- financování organizované MeSH
- luminiscenční měření MeSH
- naftaleny farmakologie chemie metabolismus MeSH
- Pseudomonas fluorescens metabolismus účinky léků MeSH
- reportérové geny MeSH
- vztahy mezi strukturou a aktivitou MeSH
- zelené fluorescenční proteiny genetika metabolismus MeSH
Seven hypotheses on relationships between the structure of naphthalene analogs and bioluminescence response of bioreporter Pseudomonas fluorescens were formulated using GUHA (General Unary Hypotheses Automaton) on a training set of 37 compounds. Prediction of bioluminescence response of 12 new naphthalene analogs was successful in 69 % cases and resulted in rejection of single hypothesis. The results demonstrate applicability of GUHA in structure-activity research, especially for qualitative data.
Citace poskytuje Crossref.org
Bibliografie atd.
Lit.: 22
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