-
Je něco špatně v tomto záznamu ?
Hypercholesterolemia, oxidative stress and gender dependence in children
Ondrejovičová I., Muchová J., Mišľanová C., Nagyová Z., Ďuračková Z.
Jazyk angličtina Země Česko
- MeSH
- antioxidancia analýza MeSH
- dinoprost analogy a deriváty krev MeSH
- dítě MeSH
- financování organizované MeSH
- hypercholesterolemie metabolismus MeSH
- lidé MeSH
- lipidové peroxidy krev MeSH
- lipidy krev MeSH
- mladiství MeSH
- oxidační stres MeSH
- pohlavní dimorfismus MeSH
- vitaminy krev MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Hypercholesterolemia (HCH) is characterized by an increase of the total- and LDL-cholesterol in serum. In hypercholesterolemia, generally recognized as a risk factor of atherogenesis, oxidative stress and oxidatively modified LDL play a crucial role. In our study, children with elevated total cholesterol (above 4.5 mmol/l) were included. Parameters of lipid profile, lipophilic vitamins and antioxidants (retinol, ?-tocopherol, ?-tocopherol, xantophyll, lycophen and ß-carotene) and markers of oxidative damage to lipids (lipoperoxides and 8-isoprostanes) were evaluated. We found that children with hypercholesterolemia have significantly increased parameters of lipid profile and these are gender dependent only in HDL-cholesterol (1.27 ± 0.10 mmol/l in boys vs. 1.53 ± 0.07 mmol/l in girls; p<0.05) and TAG (1.63 ± 0.31 mmol/l in boys vs. 1.08 ± 0.09 mmol/l in girls; p<0.05). In addition, children with HCH have decreased total antioxidant capacity of serum (TEAC) (about 19.64%, p<0.05) and increased lipoperoxides (LP) (about 45.73%, p<0.001). We have revealed statistically significant correlations between parameters of lipid profile and lipophilic vitamins and antioxidants, as well as between markers of oxidative stress: positive correlation between LP and 8-iso (r=0.353, n=33, p<0.05) and negative correlations between these parameters and TEAC (r= –0.377, n=33, p<0.05 for LP and r= –0.379, n=33, p<0.05 for 8-iso). In conclusion, we confirmed relation between hypercholesterolemia and oxidative stress and effect of gender on these processes already in childhood. Since the atherosclerotic process begins in childhood before clinical symptoms, early detection of hypercholesterolemia and oxidative stress is important in later atherosclerosis prevention.
Lit.: 34
- 000
- 00000naa 2200000 a 4500
- 001
- bmc11001679
- 003
- CZ-PrNML
- 005
- 20111210201812.0
- 008
- 110215s2010 xr e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Ondrejovičová, Iveta. $7 _AN058053
- 245 10
- $a Hypercholesterolemia, oxidative stress and gender dependence in children / $c Ondrejovičová I., Muchová J., Mišľanová C., Nagyová Z., Ďuračková Z.
- 314 __
- $a Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava
- 504 __
- $a Lit.: 34
- 520 9_
- $a Hypercholesterolemia (HCH) is characterized by an increase of the total- and LDL-cholesterol in serum. In hypercholesterolemia, generally recognized as a risk factor of atherogenesis, oxidative stress and oxidatively modified LDL play a crucial role. In our study, children with elevated total cholesterol (above 4.5 mmol/l) were included. Parameters of lipid profile, lipophilic vitamins and antioxidants (retinol, ?-tocopherol, ?-tocopherol, xantophyll, lycophen and ß-carotene) and markers of oxidative damage to lipids (lipoperoxides and 8-isoprostanes) were evaluated. We found that children with hypercholesterolemia have significantly increased parameters of lipid profile and these are gender dependent only in HDL-cholesterol (1.27 ± 0.10 mmol/l in boys vs. 1.53 ± 0.07 mmol/l in girls; p<0.05) and TAG (1.63 ± 0.31 mmol/l in boys vs. 1.08 ± 0.09 mmol/l in girls; p<0.05). In addition, children with HCH have decreased total antioxidant capacity of serum (TEAC) (about 19.64%, p<0.05) and increased lipoperoxides (LP) (about 45.73%, p<0.001). We have revealed statistically significant correlations between parameters of lipid profile and lipophilic vitamins and antioxidants, as well as between markers of oxidative stress: positive correlation between LP and 8-iso (r=0.353, n=33, p<0.05) and negative correlations between these parameters and TEAC (r= –0.377, n=33, p<0.05 for LP and r= –0.379, n=33, p<0.05 for 8-iso). In conclusion, we confirmed relation between hypercholesterolemia and oxidative stress and effect of gender on these processes already in childhood. Since the atherosclerotic process begins in childhood before clinical symptoms, early detection of hypercholesterolemia and oxidative stress is important in later atherosclerosis prevention.
- 650 _2
- $a financování organizované $7 D005381
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a antioxidancia $x analýza $7 D000975
- 650 _2
- $a dítě $7 D002648
- 650 _2
- $a dinoprost $x analogy a deriváty $x krev $7 D015237
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a hypercholesterolemie $x metabolismus $7 D006937
- 650 _2
- $a lipidové peroxidy $x krev $7 D008054
- 650 _2
- $a lipidy $x krev $7 D008055
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a oxidační stres $7 D018384
- 650 _2
- $a pohlavní dimorfismus $7 D012727
- 650 _2
- $a vitaminy $x krev $7 D014815
- 700 1_
- $a Muchová, Jana, $d 1951- $7 mzk2005273012
- 700 1_
- $a Mišľanová, Csilla. $7 xx0261457
- 700 1_
- $a Nagyová, Zuzana. $7 _AN058057
- 700 1_
- $a Ďuračková, Zdeňka $7 mzk2006355807
- 773 0_
- $w MED00013414 $t Prague medical report $g Roč. 111, č. 4 (2010), s. 300-312 $x 1214-6994
- 856 41
- $u http://pmr.cuni.cz/Data/Files/PragueMedicalReport/pmr_111_2010_4/pmr2010a0034.pdf $y plný text volně přístupný
- 910 __
- $a ABA008 $b A 7 $c 1071 $y 2
- 990 __
- $a 20110214150244 $b ABA008
- 991 __
- $a 20110725133819 $b ABA008
- 999 __
- $a ok $b bmc $g 828906 $s 693603
- BAS __
- $a 3
- BMC __
- $a 2010 $b 111 $c 4 $d 300-312 $m Prague Medical Report $x MED00013414
- LZP __
- $a 2011-03/mkme