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TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate
D Jun, P Stodulka, K Kuca, V Koleckar, B Dolezal, P Simon, M Veverka
Language English Country United States
NLK
Open Access Digital Library
from 1996-01-01
- MeSH
- Chromatography, Thin Layer methods MeSH
- Financing, Organized MeSH
- Mesylates isolation & purification MeSH
- Oximes isolation & purification MeSH
- Pyridinium Compounds chemical synthesis isolation & purification MeSH
- Cholinesterase Reactivators chemical synthesis isolation & purification MeSH
In this study, several thin-layer chromatography (TLC) methods are described for the identification of quaternary and non-quaternary compounds (parent compounds, intermediates, by-products, and products) arisen within the synthesis of the acetylcholinesterase reactivator HI-6, at present the most promising antidote in the case of nerve agent poisonings. Using the TLC technique, particular E and Z isomers of this compound on the oxime group are separated. These TLC methods could be of high interest as quick purity control for those who are interested in development of new acetylcholinesterase reactivators and the synthesis of HI-6 in laboratories or in large-scale production.
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- $a TLC analysis of intermediates arising during the preparation of oxime HI-6 dimethanesulfonate / $c D Jun, P Stodulka, K Kuca, V Koleckar, B Dolezal, P Simon, M Veverka
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- $a Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
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- $a In this study, several thin-layer chromatography (TLC) methods are described for the identification of quaternary and non-quaternary compounds (parent compounds, intermediates, by-products, and products) arisen within the synthesis of the acetylcholinesterase reactivator HI-6, at present the most promising antidote in the case of nerve agent poisonings. Using the TLC technique, particular E and Z isomers of this compound on the oxime group are separated. These TLC methods could be of high interest as quick purity control for those who are interested in development of new acetylcholinesterase reactivators and the synthesis of HI-6 in laboratories or in large-scale production.
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- $t Journal of Chromatographic Science $w MED00002734 $g Roč. 46, č. 4 (2008), s. 316-319 $x 0021-9665
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