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MCP-1 -2518 A/G single nucleotide polymorphism in Slovak patients with systemic sclerosis
Z Navratilova, J Lukac, F Mrazek, E Kriegova, M Bucova, V Bosak, M Petrek
Jazyk angličtina Země Spojené státy americké
E-zdroje NLK
Directory of Open Access Journals od 1992Free Medical Journals od 1992
Hindawi Publishing Open Access od 1992-01-01
PubMed Central od 1992
Europe PubMed Central od 1992
Open Access Digital Library od 1992-01-01
Open Access Digital Library od 1992-01-01
Open Access Digital Library od 1992-01-01
Medline Complete (EBSCOhost) od 1997-02-01
ROAD: Directory of Open Access Scholarly Resources od 1992
- MeSH
- chemokin CCL2 genetika MeSH
- dítě MeSH
- dospělí MeSH
- financování organizované MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- studie případů a kontrol MeSH
- systémová sklerodermie genetika MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (-2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 -2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 -2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; P > .05). Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population.
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- $a Laboratory of Immunogenomics, Department of Immunology, Faculty of Medicine, Palacky University, I. P. Pavlova 6, 775 20 Olomouc, Czech Republic.
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- $a Recent study in a group of German patients with SSc has implicated the SNP in the MCP-1 gene (-2518 A to G) as a factor of susceptibility to SSc. Reflecting the need for replication of genetic association studies, we investigated if this SNP is associated with SSc in another Caucasian population. MCP-1 -2518 A/G genotypes were determined using PCR-SSP in 46 SSc patients and in 449 healthy subjects, all unrelated and of Slovak (Slavonic) origin. The distribution of MCP-1 -2518 A/G genotypes complied with the Hardy-Weinberg equilibrium both in patient and healthy control groups. There was no difference in MCP-1 -2518*G allele frequency between SSc patients and healthy subjects (patients: 0.23; controls: 0.24; P > .05). Furthermore, MCP-1 -2518 GG homozygotes were similarly represented among SSc patients and healthy subjects (P > .05). The association of MCP-1 -2518 A/G SNP with SSc observed originally in German population was not replicated in the Slovak population.
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