-
Je něco špatně v tomto záznamu ?
DNA conformations and their sequence preferences
D Svozil, J Kalina, M Omelka, B Schneider
Jazyk angličtina Země Velká Británie
E-zdroje NLK
Directory of Open Access Journals od 2005Free Medical Journals od 1996
PubMed Central od 1974
Europe PubMed Central od 1974
Open Access Digital Library od 1996-01-01 do 2030-12-31
Open Access Digital Library od 1974-01-01
Open Access Digital Library od 1996-01-01
Open Access Digital Library od 1996-01-01
Medline Complete (EBSCOhost) od 1996-01-01
Oxford Journals Open Access Collection od 1996-01-01
ROAD: Directory of Open Access Scholarly Resources od 1974
- MeSH
- A-DNA chemie MeSH
- cytosin chemie MeSH
- deoxyribonukleotidy chemie MeSH
- DNA vazebné proteiny chemie MeSH
- DNA chemie MeSH
- financování organizované MeSH
- G-kvadruplexy MeSH
- konformace nukleové kyseliny MeSH
- křížová struktura DNA chemie MeSH
- ligandy MeSH
- nukleozomy chemie MeSH
- RNA chemie MeSH
- sekvence nukleotidů MeSH
The geometry of the phosphodiester backbone was analyzed for 7739 dinucleotides from 447 selected crystal structures of naked and complexed DNA. Ten torsion angles of a near-dinucleotide unit have been studied by combining Fourier averaging and clustering. Besides the known variants of the A-, B- and Z-DNA forms, we have also identified combined A + B backbone-deformed conformers, e.g. with alpha/gamma switches, and a few conformers with a syn orientation of bases occurring e.g. in G-quadruplex structures. A plethora of A- and B-like conformers show a close relationship between the A- and B-form double helices. A comparison of the populations of the conformers occurring in naked and complexed DNA has revealed a significant broadening of the DNA conformational space in the complexes, but the conformers still remain within the limits defined by the A- and B- forms. Possible sequence preferences, important for sequence-dependent recognition, have been assessed for the main A and B conformers by means of statistical goodness-of-fit tests. The structural properties of the backbone in quadruplexes, junctions and histone-core particles are discussed in further detail.
- 000
- 02669naa 2200385 a 4500
- 001
- bmc11004020
- 003
- CZ-PrNML
- 005
- 20111210202519.0
- 008
- 110303s2008 xxk e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Svozil, Daniel, $d 1971- $7 xx0145391
- 245 10
- $a DNA conformations and their sequence preferences / $c D Svozil, J Kalina, M Omelka, B Schneider
- 314 __
- $a Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic and Center for Biomolecules and Complex Molecular Systems, Flemingovo nam. 2, CZ-166 10 Prague, Czech Republic.
- 520 9_
- $a The geometry of the phosphodiester backbone was analyzed for 7739 dinucleotides from 447 selected crystal structures of naked and complexed DNA. Ten torsion angles of a near-dinucleotide unit have been studied by combining Fourier averaging and clustering. Besides the known variants of the A-, B- and Z-DNA forms, we have also identified combined A + B backbone-deformed conformers, e.g. with alpha/gamma switches, and a few conformers with a syn orientation of bases occurring e.g. in G-quadruplex structures. A plethora of A- and B-like conformers show a close relationship between the A- and B-form double helices. A comparison of the populations of the conformers occurring in naked and complexed DNA has revealed a significant broadening of the DNA conformational space in the complexes, but the conformers still remain within the limits defined by the A- and B- forms. Possible sequence preferences, important for sequence-dependent recognition, have been assessed for the main A and B conformers by means of statistical goodness-of-fit tests. The structural properties of the backbone in quadruplexes, junctions and histone-core particles are discussed in further detail.
- 650 _2
- $a sekvence nukleotidů $7 D001483
- 650 _2
- $a cytosin $x chemie $7 D003596
- 650 _2
- $a DNA $x chemie $7 D004247
- 650 _2
- $a A-DNA $x chemie $7 D044704
- 650 _2
- $a křížová struktura DNA $x chemie $7 D045566
- 650 _2
- $a DNA vazebné proteiny $x chemie $7 D004268
- 650 _2
- $a deoxyribonukleotidy $x chemie $7 D003854
- 650 _2
- $a G-kvadruplexy $7 D054856
- 650 _2
- $a ligandy $7 D008024
- 650 _2
- $a konformace nukleové kyseliny $7 D009690
- 650 _2
- $a nukleozomy $x chemie $7 D009707
- 650 _2
- $a RNA $x chemie $7 D012313
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Kalina, Jan. $7 xx0207698
- 700 1_
- $a Omelka, Marek. $7 _AN046337
- 700 1_
- $a Schneider, Bohdan, $d 1927- $7 jn20000402190
- 773 0_
- $t Nucleic Acids Research $w MED00003554 $g Roč. 36, č. 11 (2008), s. 3690-3706
- 910 __
- $a ABA008 $b x $y 1
- 990 __
- $a 20110413122744 $b ABA008
- 991 __
- $a 20110413122744 $b ABA008
- 999 __
- $a ok $b bmc $g 831360 $s 696045
- BAS __
- $a 3
- BMC __
- $a 2008 $b 36 $c 11 $d 3690-3706 $m Nucleic acids research $n Nucleic Acids Res $x MED00003554
- LZP __
- $a 2011-3B/ipme